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Database: UniProt
Entry: E6UI46_RUMA7
LinkDB: E6UI46_RUMA7
Original site: E6UI46_RUMA7 
ID   E6UI46_RUMA7            Unreviewed;      1000 AA.
AC   E6UI46;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-SEP-2017, entry version 47.
DE   RecName: Full=Endoglucanase {ECO:0000256|RuleBase:RU361166};
DE            EC=3.2.1.4 {ECO:0000256|RuleBase:RU361166};
DE   Flags: Precursor;
GN   OrderedLocusNames=Rumal_0764 {ECO:0000313|EMBL:ADU21299.1};
OS   Ruminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO
OS   2250 / 7).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Ruminococcus.
OX   NCBI_TaxID=697329 {ECO:0000313|EMBL:ADU21299.1, ECO:0000313|Proteomes:UP000006919};
RN   [1] {ECO:0000313|EMBL:ADU21299.1, ECO:0000313|Proteomes:UP000006919}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7
RC   {ECO:0000313|Proteomes:UP000006919};
RX   PubMed=21914885; DOI=10.1128/JB.05621-11;
RA   Suen G., Stevenson D.M., Bruce D.C., Chertkov O., Copeland A.,
RA   Cheng J.F., Detter C., Detter J.C., Goodwin L.A., Han C.S.,
RA   Hauser L.J., Ivanova N.N., Kyrpides N.C., Land M.L., Lapidus A.,
RA   Lucas S., Ovchinnikova G., Pitluck S., Tapia R., Woyke T., Boyum J.,
RA   Mead D., Weimer P.J.;
RT   "Complete genome of the cellulolytic ruminal bacterium Ruminococcus
RT   albus 7.";
RL   J. Bacteriol. 193:5574-5575(2011).
CC   -!- CATALYTIC ACTIVITY: Endohydrolysis of (1->4)-beta-D-glucosidic
CC       linkages in cellulose, lichenin and cereal beta-D-glucans.
CC       {ECO:0000256|RuleBase:RU361166}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 9 (cellulase E)
CC       family. {ECO:0000256|RuleBase:RU361166}.
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DR   EMBL; CP002403; ADU21299.1; -; Genomic_DNA.
DR   RefSeq; WP_013497482.1; NZ_JHYT01000063.1.
DR   ProteinModelPortal; E6UI46; -.
DR   STRING; 697329.Rumal_0764; -.
DR   EnsemblBacteria; ADU21299; ADU21299; Rumal_0764.
DR   KEGG; ral:Rumal_0764; -.
DR   eggNOG; ENOG4105E08; Bacteria.
DR   eggNOG; ENOG410XNTA; LUCA.
DR   HOGENOM; HOG000245359; -.
DR   OrthoDB; POG091H00HT; -.
DR   BioCyc; RALB697329:GIWQ-762-MONOMER; -.
DR   Proteomes; UP000006919; Chromosome.
DR   GO; GO:0008810; F:cellulase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd02850; E_set_Cellulase_N; 1.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR004197; Cellulase_Ig-like.
DR   InterPro; IPR003305; CenC_carb-bd.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR001701; Glyco_hydro_9.
DR   InterPro; IPR018221; Glyco_hydro_9_His_AS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02018; CBM_4_9; 1.
DR   Pfam; PF02927; CelD_N; 1.
DR   Pfam; PF00759; Glyco_hydro_9; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00592; GLYCOSYL_HYDROL_F9_1; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU361166};
KW   Cellulose degradation {ECO:0000256|RuleBase:RU361166};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006919};
KW   Glycosidase {ECO:0000256|RuleBase:RU361166};
KW   Hydrolase {ECO:0000256|RuleBase:RU361166,
KW   ECO:0000313|EMBL:ADU21299.1};
KW   Polysaccharide degradation {ECO:0000256|RuleBase:RU361166};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006919};
KW   Signal {ECO:0000256|RuleBase:RU361166}.
FT   SIGNAL        1     32       {ECO:0000256|RuleBase:RU361166}.
FT   CHAIN        33   1000       Endoglucanase. {ECO:0000256|RuleBase:
FT                                RU361166}.
FT                                /FTId=PRO_5005128265.
FT   DOMAIN       36    161       CBM-cenC. {ECO:0000259|Pfam:PF02018}.
FT   DOMAIN      220    318       CelD_N. {ECO:0000259|Pfam:PF02927}.
SQ   SEQUENCE   1000 AA;  112217 MW;  59FBC1F6E8B53746 CRC64;
     MHKKMKRIVA GLVAITGALS ATAASAPMSV FAKNEQIIIQ SDFNAGMGLP WRTFENAPAR
     QDFDISDGTY NITIQNNDGP ESRWDLQFLY KNFYIQKGHT YKVHWKVNSS NEGELYTRIG
     NYGGTVEVWH NNCGNDDFNQ TWECVKIAKG DNTFDAEFTA KEDMDRACWI FDYGGQGQYQ
     PVDCFPNGTV LKFDDLSLID TTSGGCIIDF IPNDWGIVRP ESNVRLNQIG YYPQLEKRAS
     YVTDADMPLT FEIRDRSGNV KYTGKTKVFG SDPDSGTGKD TVVNSVTRYK DSGANVHIID
     FSDFRTVGEY TIFVKDTVGV SGTQVMGSKK VNDTRLSGDK LLWTNPVTMK TYTMNESSTF
     RIDRQIYDDQ LLRDSMNYFY QNRSGVPIKS EYITSGDKSA LSHLKYGHNP DMAYVQSKWV
     KTYEDDFSDG EKDKKIDVTG GWYAASDHGK YVVEGGFSVW TLQNAYEFSK RSGNTRKWTD
     GTIAVPENKD NAPDILDEAR VELEWMFKMI NEDGFVYHSV QDYKWADIPI RLGPIYCTDP
     PMEYTYPYRI VRPPTYAATF NMIACAAQAS RLWKGIDDDF AKECLQNAQN SWKAIMAKQS
     NWNVTSGYYY DDPYFAPSES GGNNFFGDTY VVDDAYWAAC ELYATTGDSA YYGFLKNYKN
     YNDPSGQDKA FSLTSCLSGG ENNGSFGSFN WGNTAGLGTL SLYLSDKTSS ADRKTIVNSI
     KNIADQYIIQ MSKEGMGIPY KSATVGGYIG IGDGDVYTGY EYGSNSFVIN NAMVLAYAYD
     TDNSKYIYRN GAAEALDYLF GRNGLGFSYV SGYGDKAMRS PHHRYWAQSI DPYFPAAPSG
     VLAGGPCSDL YHDKYLRGLG YKRGTLADQK CYVDSAEAWS VNDVSGSWNA PLVWMSSFMN
     DRFGGPKPVP YPTNIKVDYS EEYHQVRFTW NKVENADRYG IAVYLAGKWR VQKQDITGTT
     YTSPKNLTPG VTYKVAIAAR VNGTWDTENA IKRACTVTIK
//
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