ID   E6UUZ4_VARPE            Unreviewed;       577 AA.
AC   E6UUZ4;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:ADU36409.1};
DE            EC=1.1.99.1 {ECO:0000313|EMBL:ADU36409.1};
GN   OrderedLocusNames=Varpa_2203 {ECO:0000313|EMBL:ADU36409.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU36409.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU36409.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU36409.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium Variovorax
RT   paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-e00813(2013).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR   EMBL; CP002417; ADU36409.1; -; Genomic_DNA.
DR   AlphaFoldDB; E6UUZ4; -.
DR   STRING; 595537.Varpa_2203; -.
DR   KEGG; vpe:Varpa_2203; -.
DR   eggNOG; COG2303; Bacteria.
DR   HOGENOM; CLU_002865_7_1_4; -.
DR   OrthoDB; 9785276at2; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003968};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU003968};
KW   Oxidoreductase {ECO:0000313|EMBL:ADU36409.1}.
FT   DOMAIN          82..105
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00623"
FT   DOMAIN          260..274
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00624"
SQ   SEQUENCE   577 AA;  61706 MW;  D34005ED8ACCDD98 CRC64;
     MEFDYVIVGG GSGGATLASR LSEDPGVTVC LIEAGGDGRG ILVRAPAATV AMLPGRPPIN
     NYAYKTVPQP ALGGRSGYQP RGRGLGGSSA INAMLYVRGH RDDYDDWARA GCEGWSFDEV
     LPYFKRAEGN ERGESALHGA GGPLQVSEQQ SPRPITEDFI RAAAECGIPR NDDFNGAEQE
     GAGLYQVTQF HGGTKNGERC SAAAAYLHPV MHARPNLKVL TGAQALRVVL DGKRATGVEV
     RRGGSTEVIR AHREVALCGG AFNSPQLLML SGIGDPAELG RHGIAVRHAL PGVGQNLQDH
     TDFILAYTSK DIDLFGIGVK AGLKLMKAIF EWRKSGKGLV ATPFAEGGAF IKSSPELRRP
     DLQLHFVIAI TDDHARKLHM GFGFSCHVCV LRPKGRGDVR LNDSNPLSAP RIDPRFLSDA
     EDMALLLQGV KKMREILRAP ALQKYRHREV YTADAHTDEE LTQHIRARAD TIYHPVGTCK
     MGVDAMAVVD AQLRVHGIEN LRVVDASVMP TLIGGNTNAP TIMIAERAAD WMRGPITFDR
     AVVDARAPAT IPAPSVPLEA AVGAVLSPAP ATARSGM
//