ID E6UWK9_VARPE Unreviewed; 498 AA.
AC E6UWK9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=TIGR01777 family protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=Varpa_5787 {ECO:0000313|EMBL:ADU39939.1};
OS Variovorax paradoxus (strain EPS).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU39939.1, ECO:0000313|Proteomes:UP000008917};
RN [1] {ECO:0000313|Proteomes:UP000008917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.;
RT "Complete sequence of Variovorax paradoxus EPS.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADU39939.1, ECO:0000313|Proteomes:UP000008917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EPS {ECO:0000313|EMBL:ADU39939.1,
RC ECO:0000313|Proteomes:UP000008917};
RX PubMed=24158554;
RA Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT "Genome of the Root-Associated Plant Growth-Promoting Bacterium Variovorax
RT paradoxus Strain EPS.";
RL Genome Announc. 1:e00843-e00813(2013).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. SDR39U1 subfamily. {ECO:0000256|ARBA:ARBA00009353}.
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DR EMBL; CP002417; ADU39939.1; -; Genomic_DNA.
DR RefSeq; WP_013544131.1; NC_014931.1.
DR AlphaFoldDB; E6UWK9; -.
DR STRING; 595537.Varpa_5787; -.
DR KEGG; vpe:Varpa_5787; -.
DR eggNOG; COG1090; Bacteria.
DR HOGENOM; CLU_042528_0_0_4; -.
DR OrthoDB; 9801773at2; -.
DR Proteomes; UP000008917; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013549; DUF1731.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR010099; SDR39U1.
DR NCBIfam; TIGR01777; yfcH; 1.
DR PANTHER; PTHR11092:SF0; EPIMERASE FAMILY PROTEIN SDR39U1; 1.
DR PANTHER; PTHR11092; SUGAR NUCLEOTIDE EPIMERASE RELATED; 1.
DR Pfam; PF08338; DUF1731; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..406
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 448..494
FT /note="DUF1731"
FT /evidence="ECO:0000259|Pfam:PF08338"
SQ SEQUENCE 498 AA; 54234 MW; 1C8E38699795204B CRC64;
MIDTHLLALQ LMAAQGLTGA FDTLYHHEGT EALAQRNTAR RELAIHAVHS SIYCAMFIGL
SSWAWHGVWA WVLLAVFGVE IVLTLWDFVV EDGSRLLPPT ERVTHTVLAI NAGAFIALLA
MNAVDWAAQP TALAWHPQGW LGAFLALCGV GVGVSGLRDG LAARALFRRT AQEETRAIKA
PVRFGTKPQR VLVTGGTGFI GQTLVRHLVA DGHAVTVWTR DARSAAWNFG GAVRCVQRLD
QIPETDPCDV VINLAGARIL GQRWSERRQQ QLLQSREGLT RTLVAWIATR PRKPWLLLSG
SAIGYYGVQP QGDAAELTED APPQDIFMST LCQRWENAAR AATAHGVHVA CMRFGFVLGH
QGSLPQLLLP VALGMGGRLG SGRQWLSWVH VHDVIRAMAH VWSAAEQAGT DGPATAQAFN
FTAPGALSQE DFTRVAASVM HRPFWMPTPA APVKLLLGEQ ADLLLEGQRV VPARLLQTGF
RFAFPDARSA LTDLCRPR
//
