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Database: UniProt
Entry: E6VSG6_DESAO
LinkDB: E6VSG6_DESAO
Original site: E6VSG6_DESAO 
ID   E6VSG6_DESAO            Unreviewed;       460 AA.
AC   E6VSG6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   05-JUL-2017, entry version 52.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   OrderedLocusNames=Daes_3321 {ECO:0000313|EMBL:ADU64309.1};
OS   Desulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=643562 {ECO:0000313|EMBL:ADU64309.1, ECO:0000313|Proteomes:UP000002191};
RN   [1] {ECO:0000313|Proteomes:UP000002191}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700646 / DSM 10631 / Aspo-2
RC   {ECO:0000313|Proteomes:UP000002191};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Chertkov O., Misra M., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G.,
RA   Pedersen K., Jagevall S., Hazen T., Woyke T.;
RT   "Complete sequence of Desulfovibrio aespoeensis Aspo-2.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002431; ADU64309.1; -; Genomic_DNA.
DR   STRING; 643562.Daes_3321; -.
DR   EnsemblBacteria; ADU64309; ADU64309; Daes_3321.
DR   KEGG; das:Daes_3321; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000227577; -.
DR   KO; K02313; -.
DR   OMA; DFRYLQG; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DAES643562:GH9Z-3343-MONOMER; -.
DR   Proteomes; UP000002191; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002191};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002191}.
FT   DOMAIN      158    280       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      367    436       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   460 AA;  53762 MW;  66E204346984A051 CRC64;
     MFFRPEFQVF FPNFPNALHN GPQQQKVIVK HSLRQHLLQT STDAELKRWF DPLHLVYEEE
     GKRIVVGFPH AFFAKWFESE VQDRFEAQLN MFLGTGYVVS YRDNGSLERG TGVKAADVIK
     RIDFPFGQEF TFDTFLINKK NYFPIASARE VAKQSASLFN PFIVCGPGGS GKTHLIRAVA
     NEISKKHDHS KIFIGSMDEL NSFYTIRFKG DPFRARNHLF EYNFLFIDDF QKIREHPHFQ
     QEVVNLFNHF YDNKKQMIIC CRDKLASYDF LDESLQSRLG WGLIVTLKEA DLEIRVGYIQ
     RQCRLKRLLL SKEQVLTLAQ HFTDFRYLQG VLLKLFAFKE LVKKEMTQRD FEHIMANTEE
     KTTDDLTPKK IMTVVSEHFS VNIKELTGTK RHQNIAQARQ VAMFLCRQLL NTSYPALGRA
     FGGKDHSTVL YSVKKIEQLQ EDDFELKQLL KKLKTKCRLP
//
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