ID E6XMX2_SHEP2 Unreviewed; 239 AA.
AC E6XMX2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Dihydromonapterin reductase {ECO:0000256|ARBA:ARBA00039631};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.50 {ECO:0000256|ARBA:ARBA00039145};
DE AltName: Full=Dihydrofolate reductase {ECO:0000256|ARBA:ARBA00042299};
GN OrderedLocusNames=Sput200_3351 {ECO:0000313|EMBL:ADV55740.1};
OS Shewanella putrefaciens (strain 200).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=399804 {ECO:0000313|EMBL:ADV55740.1, ECO:0000313|Proteomes:UP000008209};
RN [1] {ECO:0000313|EMBL:ADV55740.1, ECO:0000313|Proteomes:UP000008209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=200 {ECO:0000313|EMBL:ADV55740.1,
RC ECO:0000313|Proteomes:UP000008209};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Kolker E., Lawrence C., McCue L.A., DiChristina T., Nealson K.,
RA Fredrickson J.K., Woyke T.;
RT "Complete sequence of Shewanella putrefaciens 200.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reduction of dihydromonapterin to
CC tetrahydromonapterin. Also has lower activity with dihydrofolate.
CC {ECO:0000256|ARBA:ARBA00037508}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate +
CC H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.5.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001315};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-
CC tetrahydromonapterin + NADP(+); Xref=Rhea:RHEA:34847,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:71175, ChEBI:CHEBI:71177; EC=1.5.1.50;
CC Evidence={ECO:0000256|ARBA:ARBA00036516};
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. FolM subfamily. {ECO:0000256|ARBA:ARBA00038212}.
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DR EMBL; CP002457; ADV55740.1; -; Genomic_DNA.
DR AlphaFoldDB; E6XMX2; -.
DR KEGG; shp:Sput200_3351; -.
DR PATRIC; fig|399804.5.peg.3470; -.
DR HOGENOM; CLU_010194_1_3_6; -.
DR OrthoDB; 9793499at2; -.
DR Proteomes; UP000008209; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43639:SF6; DIHYDROMONAPTERIN REDUCTASE; 1.
DR PANTHER; PTHR43639; OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870); 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
SQ SEQUENCE 239 AA; 26191 MW; 438B7C01FC3CF9DF CRC64;
MTSPIIITGV GKRIGYALAK HLLAQGHSVI GTYRSHYPNI DKLRVLGATL IQCDFYDNVQ
VQGLIDQLSQ YPKIRAIIHN ASDWLADSSQ TFTASEVIQR MMLVHVSVPY QLNLALASQL
QAGAEEEIGA SDIIHITDYV AEKGSAKHIA YAASKAALHN LTLSFAAKFA PEVKVNSIAP
AMILFNQGDD EAYQQKTLAK ALLPKEAGSE EIIDLVEYLL NSRYVTGRSH HVDGGRHLR
//
