ID E6YXX9_BARSR Unreviewed; 615 AA.
AC E6YXX9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:CBI81717.1};
GN ORFNames=B11C_10191 {ECO:0000313|EMBL:CBI81717.1}, BscR1v2_001990
GN {ECO:0000313|EMBL:AQX30154.1};
OS Bartonella schoenbuchensis (strain DSM 13525 / NCTC 13165 / R1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=687861 {ECO:0000313|EMBL:CBI81717.1};
RN [1] {ECO:0000313|EMBL:CBI81717.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=R1 {ECO:0000313|EMBL:CBI81717.1};
RX PubMed=21347280; DOI=10.1371/journal.pgen.1001296;
RA Engel P., Salzburger W., Liesch M., Chang C.C., Maruyama S., Lanz C.,
RA Calteau A., Lajus A., Medigue C., Schuster S.C., Dehio C.;
RT "Parallel evolution of a type IV secretion system in radiating lineages of
RT the host-restricted bacterial pathogen Bartonella.";
RL PLoS Genet. 7:E1001296-E1001296(2011).
RN [2] {ECO:0000313|Proteomes:UP000190811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1 {ECO:0000313|Proteomes:UP000190811};
RX PubMed=28338931; DOI=10.1093/gbe/evx042;
RA Harms A., Segers F.H., Quebatte M., Mistl C., Manfredi P., Korner J.,
RA Chomel B.B., Kosoy M., Maruyama S., Engel P., Dehio C.;
RT "Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent
RT Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella.";
RL Genome Biol. Evol. 9:761-776(2017).
RN [3] {ECO:0000313|EMBL:AQX30154.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1 {ECO:0000313|EMBL:AQX30154.1};
RA Harms A., Segers F.H.I.D., Quebatte M., Mistl C., Manfredi P., Koerner J.,
RA Chomel B., Kosoy M., Maruyama S., Engel P., Dehio C.;
RT "Evolutionary dynamics of pathoadaptation revealed by three independent
RT acquisitions of the VirB/D4 type IV secretion system in Bartonella.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CP019789; AQX30154.1; -; Genomic_DNA.
DR EMBL; FN645506; CBI81717.1; -; Genomic_DNA.
DR AlphaFoldDB; E6YXX9; -.
DR STRING; 687861.BscR1v2_001990; -.
DR Proteomes; UP000190811; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 210..328
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 429..572
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 615 AA; 67155 MW; BE08F25BD56EFE22 CRC64;
MIIRHLSETI INQIAAGEVI ERPANVVKEL VENAIDAGAT RIEIVTANGG KNLIRVSDNG
CGIPKDQLTL AISRHCTSKL VDDVHNICFL GFRGEALPSI GSVAKLKLVS RTQDADSAAE
IIVTAGKIEG PKPAAANSGT TVEVRDLFFV TPARLKFMKT DSAEMNAITD MIKRIAIAFP
HIRFSLSGKD RTLIELPATE NNTQGQLERI TQIMGKEFGS NTITLNAERE TARLTGFACL
PSFNRGNSLH QFVYVNGRPV RDKFLSGAIR GAYTDVMAPN RHAVSILFID LPPADVDVNV
HPAKADVRFR DPGLIRGLII GAIHEALRQT GIRPSSTGSK AMLAAFQRQS SFKTFRSPSP
HQPFSYSPQP QYVAPGTTSA DHKPVDIPDF SGLREDITPM IEYVNTPSSD VGFVNTSTSE
ELYYPLGAAK AQIHKNYIVA QTKNSLIIVD QHAAHERLVY EALKNALYSK PLPSQLLLIP
EIVELSEEDA ACLLVHKDVL QKFGLGIEAF GSGAIVVRET PTMLGEINAQ ALIKDLVDEA
SEYDTTDNLK AMLNHVAATM ACHSSIRSGR LLHPKEMNAL LRQMEATPNS STCNHGRPTY
IELKLADIER LFGRK
//
