ID E6ZIZ0_DICLA Unreviewed; 1302 AA.
AC E6ZIZ0;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN Name=NPHP3 {ECO:0000313|EMBL:CBN82024.1};
GN ORFNames=DLA_XVIII02820 {ECO:0000313|EMBL:CBN82024.1};
OS Dicentrarchus labrax (European seabass) (Morone labrax).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Moronidae; Dicentrarchus.
OX NCBI_TaxID=13489 {ECO:0000313|EMBL:CBN82024.1};
RN [1] {ECO:0000313|EMBL:CBN82024.1}
RP NUCLEOTIDE SEQUENCE.
RA Kuhl H., Tine M., Hecht J., Knaust F., Reinhardt R.;
RT "Analysis of single nucleotide polymorphisms in three chromosomes of
RT European sea bass Dicentrarchus labrax.";
RL Comp. Biochem. Physiol. Part D Genomics Proteomics 6:70-75(2011).
RN [2] {ECO:0000313|EMBL:CBN82024.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.ygeno.2011.06.004;
RA Kuhl H., Tine M., Beck A., Timmermann B., Kodira C., Reinhardt R.;
RT "Directed sequencing and annotation of three Dicentrarchus labrax L.
RT chromosomes by applying Sanger- and pyrosequencing technologies on pooled
RT DNA of comparatively mapped BAC clones.";
RL Genomics 0:0-0(2011).
RN [3] {ECO:0000313|EMBL:CBN82024.1}
RP NUCLEOTIDE SEQUENCE.
RA Tine M., Kuhl H., Beck A., Bargelloni L., Reinhardt R.;
RT "Comparative analysis of intronless genes in teleost fish genomes: Insights
RT into their evolution and molecular function.";
RL Mar. Genomics 4:109-119(2011).
RN [4] {ECO:0000313|Ensembl:ENSDLAP00005073809.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; FQ310508; CBN82024.1; -; Genomic_DNA.
DR Ensembl; ENSDLAT00005079603.1; ENSDLAP00005073809.1; ENSDLAG00005010863.2.
DR GeneTree; ENSGT00940000156398; -.
DR Proteomes; UP000694389; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 3.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 5.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000694389};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 961..994
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1111..1144
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1153..1186
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1195..1228
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1237..1270
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1283..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 82..180
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1302 AA; 147866 MW; 92D44C5F7CA1FA92 CRC64;
MGTASSLVSP GEVIEDGYGG EGGEACEIPV EVKPKARLLR SSFRRGPRVI GASFKSTGSV
DLEYAAEYER LRKEYEIFRV SKNNEISSMQ KKEAKLDEEN KRLRAELQAL QKTYQKILRE
KESALEAKYQ AMERAATFEH DRDKVKRQFK IFRETKEKEI QDLLRAKRDL EAKLQQLQAQ
GIQVYDPNDS DSDDNQTTVT AAGTQCEYWS GGVLGSEPSM GSMMQLQQTF RGPEFAHSLI
DVEGPFANVS RDDWDAAVAS LLQVSPHVPQ ALWSNTVRCY LIFTKETKAE LDIFIKKHSP
VLRKMCEGLG HFFLNVCFPE ESSASYTVER KQEIERSSVC VLLLNSTVTS SVVEDCEEAF
VKNPEGHPLV LYLRTEEDHN LTGPTRQLLE RVNAADKAAK VKVVDHNGSA EEGADLIYAQ
LEKVIKQELL GLEGADVDSK DSGIEEGREE DSGDVLWDLH DEQEQIESYQ QACNSTNSQL
GFQKYIDRLN DMIAAPPPTP PLLVSGGPGS GKSLLLSKWI EQQQKQSPNT LFLYHFVGRP
LSTSSEPVLI IKRLTVKLLQ HFWSISGLSM EPSKILEEFP RWLERLSARH QGNIMIIIDS
IDQIQQAERH MKWLIDPLPV NVRVVVSVNV ETCPQAWRLW PTLHLDPLSP REVRSLVNAE
CQSMDLKFTK DEEKKLERHC RSASTCNALY VTLLARMIIS GISCWSLEKS LEQCLQCQDT
MSLYRQALKI TLNSLNTDRE RHIMREILCL VCASHNGVSE SEVLDHFPDV EFPVLSSLLY
HLNRLCIVTL RCGLIRFQHL QAWEAVRLEF LGGGSSSAAY REKLIHYFSQ QLSQDRVTWR
VADELPWLLQ QQEDRTKLQL SLLNLFVSQN LYKRGHFSEL LAYWQYVGKD KSSMATEYFE
SLKHYEKSCE SEDGMTKLAN LYETLGRFLK DLGLPSQAVA PLQRSLEIRE TALDPDHPSV
ARSLHQLAGV YVQWKKYGNA EQLYKQALEI SENAYGAEHV SVARELESLA MLYQKQNKYE
QAEKLGKMSV KIRQKTARQK GHMYGFTLLR RRALQLEELT LGKDSADCAK TLNELGVLYY
LQNNLDAAKI FLTRSLEMRQ RVLGPDHPDC AQSLNNLAAL HTERREYETA EDMYERALDI
RKKALSPDHP SLAYTLKHLA MLYKRRGKLE KAVPLYELSL EIREKSFGPK HPSVATALVN
LAVIYCQLKK HSEALPLYER ALKVYEDSLG RSHPRVGETL KNLAVLSYEE GDFERAAELY
KRAMEIKEAE PSLVCGNALS RHSSSGDTFS LRGPAAVPHA PR
//
