ID E6ZJ30_DICLA Unreviewed; 665 AA.
AC E6ZJ30;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Zinc transporter ZIP12 {ECO:0000256|ARBA:ARBA00040591};
DE AltName: Full=Solute carrier family 39 member 12 {ECO:0000256|ARBA:ARBA00042541};
DE AltName: Full=Zrt- and Irt-like protein 12 {ECO:0000256|ARBA:ARBA00042971};
GN Name=SLC39A12 {ECO:0000313|EMBL:CBN82064.1};
GN ORFNames=DLA_XVIII03230 {ECO:0000313|EMBL:CBN82064.1};
OS Dicentrarchus labrax (European seabass) (Morone labrax).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Moronidae; Dicentrarchus.
OX NCBI_TaxID=13489 {ECO:0000313|EMBL:CBN82064.1};
RN [1] {ECO:0000313|EMBL:CBN82064.1}
RP NUCLEOTIDE SEQUENCE.
RA Kuhl H., Tine M., Hecht J., Knaust F., Reinhardt R.;
RT "Analysis of single nucleotide polymorphisms in three chromosomes of
RT European sea bass Dicentrarchus labrax.";
RL Comp. Biochem. Physiol. Part D Genomics Proteomics 6:70-75(2011).
RN [2] {ECO:0000313|EMBL:CBN82064.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.ygeno.2011.06.004;
RA Kuhl H., Tine M., Beck A., Timmermann B., Kodira C., Reinhardt R.;
RT "Directed sequencing and annotation of three Dicentrarchus labrax L.
RT chromosomes by applying Sanger- and pyrosequencing technologies on pooled
RT DNA of comparatively mapped BAC clones.";
RL Genomics 0:0-0(2011).
RN [3] {ECO:0000313|EMBL:CBN82064.1}
RP NUCLEOTIDE SEQUENCE.
RA Tine M., Kuhl H., Beck A., Bargelloni L., Reinhardt R.;
RT "Comparative analysis of intronless genes in teleost fish genomes: Insights
RT into their evolution and molecular function.";
RL Mar. Genomics 4:109-119(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; FQ310508; CBN82064.1; -; Genomic_DNA.
DR AlphaFoldDB; E6ZJ30; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR049406; ZIP4_12_EF-hand.
DR InterPro; IPR041137; ZIP4_N.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF4; ZINC TRANSPORTER ZIP12; 1.
DR Pfam; PF21116; EF-hand_Zip; 1.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..665
FT /note="Zinc transporter ZIP12"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003214558"
FT TRANSMEM 375..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..233
FT /note="Zinc transporter ZIP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18292"
FT DOMAIN 241..356
FT /note="Zinc transporter ZIP4/12 EF-hand"
FT /evidence="ECO:0000259|Pfam:PF21116"
FT REGION 274..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 73136 MW; E4DA22C42A3D013F CRC64;
MNSRSTAPAL LLLLLCLLGR VQEVKGQEQE YLQEALRALD LPLGTDNEPQ LQKNHTGILI
ATLLRAVHCA ERLGTSQDAC DRCLTPDVAL SVLEDDGKAY FTKEEYQRIS TLLLYYIINL
QDLCVSNAAS PASLSSSSSS SFGNYQFYLL ALINLHPAED DRFLSSSETE SILQLINQHY
DPSNQDTSSD SECIDATALL EDVNVKENPG AGVSSVPKLA AAIISHILQG HCFRRKNLPT
PAFFTDYIFH SLNRTSNLQI IDLEELLHQL GVGQQGVTDS HDRKRRSITK RSQKGAGPPL
DGCNHESGGL RQDWAQVCFS ANQLVDIFAL NPHLPISKEH FRQICPAIIQ QLLGNACESA
EQKRRGSLPT ALEKYGYSTA AVLLITVGSM LGICLIFFSS CQETYTLILQ LFVGLAVGTL
SGDALLHLIP QILGLHDDTH SHADEHFTEG KEYLWRILGM IAGIYGFFLI ERIFSFVVPS
HGHGPVDDLE CTEVSPEHSD IRRPSHQRRG VPLLAVMVIV GDSLHNFADG LVVGAAFSAS
AETGMATTVA ILCHEIPHEM GDFAVLLSSG LSVKTAVLMN FLSALTAFMG LYIGLFVSSE
MEVQRWIFAV TAGIFLYLSL VEMLPEMNRV QTDRPCLMFL LQNLGLLMGW ACLLLLALFE
HELKL
//
