ID E7BXD1_LARCR Unreviewed; 953 AA.
AC E7BXD1;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Toll-like receptor 22 {ECO:0000313|EMBL:ADK77870.1};
OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Larimichthys.
OX NCBI_TaxID=215358 {ECO:0000313|EMBL:ADK77870.1};
RN [1] {ECO:0000313|EMBL:ADK77870.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20974258; DOI=10.1016/j.fsi.2010.10.014;
RA Xiao X., Qin Q., Chen X.;
RT "Molecular characterization of a Toll-like receptor 22 homologue in large
RT yellow croaker (Pseudosciaena crocea) and promoter activity analysis of its
RT 5'-flanking sequence.";
RL Fish Shellfish Immunol. 30:224-233(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; GU324977; ADK77870.1; -; mRNA.
DR RefSeq; NP_001290325.1; NM_001303396.1.
DR AlphaFoldDB; E7BXD1; -.
DR GeneID; 104928758; -.
DR KEGG; lco:104928758; -.
DR OrthoDB; 1207361at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 17.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ADK77870.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..953
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003217511"
FT TRANSMEM 747..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 794..935
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 953 AA; 109199 MW; 804FE10D606A1262 CRC64;
MPRGRAKYFK LSIMFLLLNI DNVVVPVRGF SLRSCRISYS TAICAKSRPS LKAVPKDIPP
TVTGLDLSLN KITKIQGSDF KNLPLLTQLE IDRNMISQID TGAFANLISL KNLNLNNNKL
HELRADLFDG LGNLTELRIR SNGIKVVAST SFKSLTSLKL LDISFNRLNH LTNVHAIIQH
LPNLKDLSIY GNGFTTFNSW ELTNSSLGLT SLDVSQNPFG VFNITTDIFP DLTRFNIGGF
HSKQHMKWEV RNTTFPSQVS TLDISGIELA FGHMKTFLES VNSSLISMRM NSMKYNLTAL
INVSCTIPTM STLQLRRNKL HFIRSNLFKL SINVTELDLA ESRIKNIHDE AFASMQGLKI
LTLSRNSLHS VPPATKYIPT LEELDLSKNN ITTLGCQDFA NMTKLKHLRL FNNFISALND
CVFKDLIQLQ VLKLQGNHIC KFGGAFKKPN LPNLTQLRLN GNGLTTIQSE AFNGLQSLQM
LSLHENKIKN LEDGCFIGLT DLTDLQLQSN NINQSVIRQE VFNHLTNLRR LDLRTNHIRY
NYSSAMPNPP FSKLSHLQIL AIPGQHRRGK SLLPSNLLQG LTNLLVFNTR NTQLLSLSKD
MFNHTPQLQI LDISSNDIVD LSPELFFPIQ NLKSLYISRI SLRSLDFLKD AGLTKLESMQ
ARKNAFSVLS EDEMDPLKAL VYLDLLGNSF TCDCDNAWFI NWTENSNKTQ VFDAYNFECN
YPPDLKGMKL LDFDIRFCKV STDFICFVST TCMVLLFMVV SFTYHFLRWQ LTYAYYYFLA
LLFNSKNQNR QAANLYDAFI SYNTHDEPWV IQELLPKLEG EQGWRLCLHH RDFEPGKPII
ENITDAIYAS RKTICVISRR YPESEWCSRE IQVASFRLFD ERKDVLILVF LEEIPTYEMS
PHHRMRKLLK RQTYLSWPQV GEHTEVFWEK LRKALRAEEE GLNEDRLLLT VMD
//
