ID   E7CBP5_9REOV            Unreviewed;       175 AA.
AC   E7CBP5;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Nonstructural protein {ECO:0000313|EMBL:ADR83702.1};
DE   Flags: Fragment;
OS   Human rotavirus A.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus; Rotavirus A.
OX   NCBI_TaxID=10941 {ECO:0000313|EMBL:ADR83702.1};
RN   [1] {ECO:0000313|EMBL:ADR83702.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=079230 {ECO:0000313|EMBL:ADR83702.1};
RX   PubMed=20542145; DOI=10.1016/j.meegid.2010.05.017;
RA   Tatte V.S., Rawal K.N., Chitambar S.D.;
RT   "Sequence and phylogenetic analysis of the VP6 and NSP4 genes of human
RT   rotavirus strains: evidence of discordance in their genetic linkage.";
RL   Infect. Genet. Evol. 10:940-949(2010).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GU815236; ADR83702.1; -; Genomic_RNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.430; -; 1.
DR   HAMAP; MF_04091; ROTA_NSP4; 1.
DR   InterPro; IPR002107; Rotavirus_NSP4.
DR   Pfam; PF01452; Rota_NSP4; 1.
DR   SUPFAM; SSF58030; Rotavirus nonstructural proteins; 1.
PE   3: Inferred from homology;
KW   Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023050};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          85..112
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADR83702.1"
SQ   SEQUENCE   175 AA;  20391 MW;  2945ABD5E2848738 CRC64;
     MEKFTDLNYT LSVITLMNST LHTILEDPGM AYFPYIASVL TVLFTLHKAS IPTMKIALKT
     SKCSYKVVKY CIVTILNTLL KLAGYKEQIT TKDEIEKQMD RVVKEMRRQL EMIDKLTTRE
     IEQVELLKRI YDKLIVRSTD EIDMTKEINQ KNVRTLEEWE SGKNPYEPKE VTAAM
//