ID E7CHR9_ONCMY Unreviewed; 958 AA.
AC E7CHR9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Nucleotide-binding oligomerization domain-containing protein 2 {ECO:0000256|ARBA:ARBA00044203};
DE AltName: Full=Caspase recruitment domain-containing protein 15 {ECO:0000256|ARBA:ARBA00044293};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:ADV31550.1};
RN [1] {ECO:0000313|EMBL:ADV31550.1}
RP NUCLEOTIDE SEQUENCE.
RA Chang M.X., Nie P., Wang T.H., Zou J., Secombes C.J.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV31550.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20888918; DOI=10.1016/j.fsi.2010.09.014;
RA Chang M., Wang T., Nie P., Zou J., Secombes C.J.;
RT "Cloning of two rainbow trout nucleotide-binding oligomerization domain
RT containing 2 (NOD2) splice variants and functional characterization of the
RT NOD2 effector domains.";
RL Fish Shellfish Immunol. 30:118-127(2011).
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR EMBL; HM133907; ADV31550.1; -; mRNA.
DR RefSeq; NP_001188484.1; NM_001201555.1.
DR AlphaFoldDB; E7CHR9; -.
DR GeneID; 100529152; -.
DR KEGG; omy:100529152; -.
DR CTD; 64127; -.
DR OrthoDB; 3087860at2759; -.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08788; CARD_NOD2_2_CARD15; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF64; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 75..156
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 242..379
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 958 AA; 106968 MW; 8CBD0AA56B98D110 CRC64;
MLFREDYQNV LVPCRGLCAN TRVLLDLVYT KGDETCRLLL AAFKQVLPEA QRAGLSFGNC
RTADLENTRD DTRELHGTAI QTLQTGRPDL VRRLRDHIEG ALEVLLHTGS FTPSDCNEVQ
LPVYTPSQQA RHLLDQVRSK GEPAAKVLLQ YFQQTEDHPS PSNQEAPPKE CLSYQKKLRS
TVSAQSHFLR TYGGTSSLSL EDIYTEGQLE LAQGDSEAQP QTGALGLEDV VGLVGTLNQE
ADTVLVSGEA GSGKSTLLQR LHLLWARGAA LHDFFLLFSF SCRRLSSEQR ELSLRELLFL
HCCWPDGDQD RIFQFILDHP HLILFTFDGL DELMQSFSDS EQRHCCPTQC APVPTLLFNL
LQGSLMKGVR KVVTSRPEAV GPTLKRYLRK EVLLKGFSPG GIDCFVRKHH RDPTVATRVL
ESLRSNTALL GLCHIPVFCW IVSKCYKELL GCGEGEGSPQ TITYVYLMIL HHFFQRRASQ
RNTMGIGWVQ EHHDTALHLG QLAMEGLGAS CYIFTGTKLQ KCGVTEEDIC LGFLIRSKNL
SSSTNCKHYE FLHITMQCFF AALYIVLNNN SDRSTIPKLF HLQDRQQQPG FHRACLGHCL
TQQEGALKEA NKAAETPNLQ ITATFVSGLL AQRHRSLLLL SCPGPTLDRK SKQVVTCLSK
GIQKHFKSIP RPVEGEKKSM HAMPGFVWLI KCIHEVQDSR IARDTMAKLE VEHLKLAYCN
IGPGECTALA YVLQHLRNPV GLQLDYNYVG DVGVEQLLPC LHVCHSVYLR HNNISDEGVR
KLIEKGIQCE RFQKIALFNN KLTDACTECF AHLLKMKQNF LSLRLGNNNI TAAGAGQLAE
GLRFNRSLQF LGLWGNKIGD KGAEAIANAL KDSQTLVWLS LVDNGVGNAG ACALAPLIKN
STLEELWLTK NCITRTGVEC LILALESNTS VKAVWLRGNE LSPEEVEEMT QREPRLTF
//