ID E7CQD4_IGUDE Unreviewed; 162 AA.
AC E7CQD4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NT3 {ECO:0000313|EMBL:ADI61912.1};
OS Iguana delicatissima (Lesser Antillean iguana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Iguanidae; Iguaninae; Iguana.
OX NCBI_TaxID=51191 {ECO:0000313|EMBL:ADI61912.1};
RN [1] {ECO:0000313|EMBL:ADI61912.1}
RP NUCLEOTIDE SEQUENCE.
RA Stephen C.L., Reynoso V.H., Collett W.S., Hasbun C.R., Breinholt J.W.;
RT "Geographical structure and cryptic lineages within common green iguanas,
RT Iguana iguana.";
RL J. Biogeogr. 40:50-62(2013).
RN [2] {ECO:0000313|EMBL:AVI01001.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29471487;
RA van den Burg M.P., Meirmans P.G., van Wagensveld T., Kluskens B.,
RA Madden H., Welch M.E., Breeuwer J.A.J.;
RT "The Lesser Antillean Iguana (Iguana delicatissima) on St. Eustatius:
RT Genetically Depauperate and Threatened by Ongoing Hybridization.";
RL J. Hered. 109:426-437(2018).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; HM352528; ADI61912.1; -; Genomic_DNA.
DR EMBL; MF191675; AVI01001.1; -; Genomic_DNA.
DR AlphaFoldDB; E7CQD4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 122..162
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADI61912.1"
FT NON_TER 162
FT /evidence="ECO:0000313|EMBL:ADI61912.1"
SQ SEQUENCE 162 AA; 18593 MW; CA2181DC63B815AD CRC64;
RSLPEESINS LIIKLIQADI LKNKISKQMV DVKNNVQNTM KKMDTIEPYT DGNDNMKLDF
QPVISIETEL LRQQKHYSSP RVLLSDNTPL EPPPLYLMED YIGDSEVKNR TSRQRRFAEN
KSHRGEYSVC DSESRWVTDK SSAIDIRGHQ VTVLGEIKMG PS
//
