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Database: UniProt
Entry: E7EQ78_HUMAN
LinkDB: E7EQ78_HUMAN
Original site: E7EQ78_HUMAN 
ID   E7EQ78_HUMAN            Unreviewed;       850 AA.
AC   E7EQ78;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   25-OCT-2017, entry version 62.
DE   SubName: Full=Transient receptor potential cation channel subfamily V member 1 {ECO:0000313|Ensembl:ENSP00000409627};
GN   Name=TRPV1 {ECO:0000313|Ensembl:ENSP00000409627};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409627, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000409627, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000409627}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000409627}.
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DR   EMBL; AC027796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FJ695206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EQ78; -.
DR   PaxDb; E7EQ78; -.
DR   PRIDE; E7EQ78; -.
DR   Ensembl; ENST00000425167; ENSP00000409627; ENSG00000196689.
DR   UCSC; uc010vro.3; human.
DR   EuPathDB; HostDB:ENSG00000196689.11; -.
DR   HGNC; HGNC:12716; TRPV1.
DR   OpenTargets; ENSG00000196689; -.
DR   eggNOG; KOG3676; Eukaryota.
DR   eggNOG; ENOG4110DG4; LUCA.
DR   GeneTree; ENSGT00550000074425; -.
DR   OMA; VEEVNWN; -.
DR   OrthoDB; EOG091G01LY; -.
DR   PhylomeDB; E7EQ78; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000196689; -.
DR   ExpressionAtlas; E7EQ78; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 2.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR024862; TRPV.
DR   InterPro; IPR024863; TRPV1.
DR   InterPro; IPR008347; TRPV1-4_channel.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   PANTHER; PTHR10582:SF17; PTHR10582:SF17; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01768; TRPVRECEPTOR.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    445    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    486    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    525    542       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    548    567       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    588    610       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    669    693       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      201    351       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      201    233       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   850 AA;  96142 MW;  EA2DC845AB70FF60 CRC64;
     MKKWSSTDLG AAADPLQKDT CPDPLDGDPN SRPPPAKPQL STAKSRTRLF GKGDSEEAFP
     VDCPHEEGEL DSCPTITVSP VITIQRPGDG PTGARLLSQD SVAASTEKTL RLYDRRSIFE
     AVAQNNCQDL ESLLLFLQKS KKHLTDNEFK DPETGKTCLL KAMLNLHDGQ NTTIPLLLEI
     ARQTDSLKEL VNASYTDSYY KGQTALHIAI ERRNMALVTL LVENGADVQA AAHGDFFKKT
     KGRPGFYFGE LPLSLAACTN QLGIVKFLLQ NSWQTADISA RDSVGNTVLH ALVEVADNTA
     DNTKFVTSMY NEILMLGAKL HPTLKLEELT NKKGMTPLAL AAGTGKIGVI ENGPPLSFMV
     LAYILQREIQ EPECRHLSRK FTEWAYGPVH SSLYDLSCID TCEKNSVLEV IAYSSSETPN
     RHDMLLVEPL NRLLQDKWDR FVKRIFYFNF LVYCLYMIIF TMAAYYRPVD GLPPFKMEKT
     GDYFRVTGEI LSVLGGVYFF FRGIQYFLQR RPSMKTLFVD SYSEMLFFLQ SLFMLATVVL
     YFSHLKEYVA SMVFSLALGW TNMLYYTRGF QQMGIYAVMI EKMILRDLCR FMFVYIVFLF
     GFSTAVVTLI EDGKNDSLPS ESTSHRWRGP ACRPPDSSYN SLYSTCLELF KFTIGMGDLE
     FTENYDFKAV FIILLLAYVI LTYILLLNML IALMGETVNK IAQESKNIWK LQRAITILDT
     EKSFLKCMRK AFRSGKLLQV GYTPDGKDDY RWCFRVDEVN WTTWNTNVGI INEDPGNCEG
     VKRTLSFSLR SSRVSGRHWK NFALVPLLRE ASARDRQSAQ PEEVYLRQFS GSLKPEDAEV
     FKSPAASGEK
//
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