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Database: UniProt
Entry: E7EUE6_HUMAN
LinkDB: E7EUE6_HUMAN
Original site: E7EUE6_HUMAN 
ID   E7EUE6_HUMAN            Unreviewed;      1364 AA.
AC   E7EUE6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-SEP-2017, entry version 52.
DE   SubName: Full=Sodium channel protein type 3 subunit alpha {ECO:0000313|Ensembl:ENSP00000403348};
DE   Flags: Fragment;
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSP00000403348};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403348, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000403348, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000403348}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000403348}.
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DR   EMBL; AC013463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EUE6; -.
DR   PaxDb; E7EUE6; -.
DR   PeptideAtlas; E7EUE6; -.
DR   PRIDE; E7EUE6; -.
DR   Ensembl; ENST00000440431; ENSP00000403348; ENSG00000153253.
DR   UCSC; uc061pdk.1; human.
DR   EuPathDB; HostDB:ENSG00000153253.15; -.
DR   HGNC; HGNC:10590; SCN3A.
DR   OpenTargets; ENSG00000153253; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   ChiTaRS; SCN3A; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000153253; -.
DR   ExpressionAtlas; E7EUE6; baseline and differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 3.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    124    147       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    192    211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    223    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    400    427       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    712    730       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    742    765       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    822    850       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    912    935       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1158   1176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1197   1219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1225   1244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1289   1309       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      127    434       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      507    624       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      625    661       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      712    940       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      949   1151       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1156   1363       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      424    465       {ECO:0000256|SAM:Coils}.
FT   NON_TER    1364   1364       {ECO:0000313|Ensembl:ENSP00000403348}.
SQ   SEQUENCE   1364 AA;  154494 MW;  5B7A919F12E84883 CRC64;
     MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK PNSDLEAGKN
     LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVMNKGKAIF RFSATSALYI LTPLNPVRKI
     AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL
     EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD
     SNGTFVNVTM STFNWKDYIG DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN
     YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL
     AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGIGGLGE
     LLESSSEASK LSSKSAKEWR NRRKKRRQRE HLEGNNKGER DSFPKSESED SVKRSSFLFS
     MDGNRLTSDK KFCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST
     FEDSESRRDS LFVPHRHGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS SGRQRAVSIA
     SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV KHLVNLIVMD PFVDLAITIC
     IVLNTLFMAM EHYPMTEQFS SVLTVGNLVF TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG
     IIVSLSLMEL GLSNVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL
     AIIVFIFAVV GMQLFGKSYK ECVCKINDDC TLPRWHMNDF FHSFLIVFRV LCGEWIETMW
     DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN EMNNLQIAVG
     RMQKGIDYVK NKMRECFQKA FFRKPKVIEI HEGNKIDSCM SNNTGIEISK ELNYLRDGNG
     TTSGVGTGSS VEKYVIDEND YMSFINNPSL TVTVPIAVGE SDFENLNTEE FSSESELEES
     KEKLNATSSS EGSTVDVVLP REGEQAETEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG
     KIWWNLRKTC YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY
     IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA IKSLRTLRAL
     RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCVNMTT
     GNMFDISDVN NLSDCQALGK QARWKNVKVN FDNVGAGYLA LLQV
//
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