ID E7EY87_DANRE Unreviewed; 693 AA.
AC E7EY87; A0A8M2BKF2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=UV radiation resistance-associated gene {ECO:0000313|Ensembl:ENSDARP00000111856, ECO:0000313|RefSeq:XP_005172712.1};
GN Name=uvrag {ECO:0000313|Ensembl:ENSDARP00000111856,
GN ECO:0000313|RefSeq:XP_005172712.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-924};
GN Synonyms=Uvrag1 {ECO:0000313|RefSeq:XP_005172712.1}, zgc:56164
GN {ECO:0000313|RefSeq:XP_005172712.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000111856};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000111856}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000111856};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000111856, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000111856};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005172712.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005172712.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR293504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR388187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT573228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU464123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005172712.1; XM_005172655.2.
DR PaxDb; 7955-ENSDARP00000111856; -.
DR PeptideAtlas; E7EY87; -.
DR Ensembl; ENSDART00000129395; ENSDARP00000111856; ENSDARG00000023815.
DR Ensembl; ENSDART00000129395.3; ENSDARP00000111856.1; ENSDARG00000023815.8.
DR GeneID; 394044; -.
DR AGR; ZFIN:ZDB-GENE-040426-924; -.
DR CTD; 7405; -.
DR ZFIN; ZDB-GENE-040426-924; uvrag.
DR eggNOG; KOG2896; Eukaryota.
DR HOGENOM; CLU_009375_2_0_1; -.
DR OMA; HVDQNCV; -.
DR OrthoDB; 5481315at2759; -.
DR PhylomeDB; E7EY87; -.
DR TreeFam; TF323546; -.
DR Reactome; R-DRE-1632852; Macroautophagy.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000023815; Expressed in blastula and 22 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0000323; C:lytic vacuole; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0030318; P:melanocyte differentiation; IMP:ZFIN.
DR GO; GO:0035493; P:SNARE complex assembly; IBA:GO_Central.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR018791; UV_resistance/autophagy_Atg14.
DR PANTHER; PTHR15157; UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN; 1.
DR PANTHER; PTHR15157:SF5; UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN; 1.
DR Pfam; PF10186; ATG14; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7EY87};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 20..145
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 77629 MW; 169D86A42C4182D9 CRC64;
MNSIAGRDLS VSAGSVSGNP GATSSRVLHV ELTSQQRRLR HLRSIAARNI VNKNGSPLLD
TYFTLHLCQD DQISRDFYKS EVIRDSLNPT WRSLDFAMLP DLLDTSVSCF VVRIWGGREE
HYQLLIEWKV NLDGLRFTGQ QIRSRNPNEI IFGLNDGYYA AEFDQKESSD RRKNSLLQVD
QSSVRNSYSV FSLLRLRMAQ RAIKQTQVTV QKIGKEIEEK LRTTASCTEK KKERECMQLR
IGILRCELER QKKALTREMD VMQKERAQLI KKEEASSTKQ QDLESERTTL TDLQKECTAK
RELFLKSKAQ LTFRCRQLIS ELSYIYPIDV NNQNDYVICG VKLPNSEDFQ AKDDGSIAVA
LGYTAHLVLM ISCFLQIPLR YPVIHKGSRS TIKDTITDKL TEKEREFPLY PRGERFQFEY
GVYLLNKNIA QLRYQHGLST PDLRQTLPNL KNFLEHGLLV RCDRHHASMS IPVPLKSHLS
VSTASEVGFP ALSSSPEQDV RRRAASDADK QKCRTPPPSY NTAMAQPDPM TTPELQSEPS
VEVLEVGKAV ETLEDGETVS EEHPEKPLDV PTDIVSTLPS DSIPQHPGAM NGSAVPTSGG
VGLGVASGGE VCCSVEQAEE IMGTEATGLG LGLGGGARLD DYPCIPVEHA VAVECDEQVL
GEFDAAGIEE VSRRIYALEN MSSFRRPRKN SEK
//
