ID E7F2P6_DANRE Unreviewed; 518 AA.
AC E7F2P6; A0A8M2BFZ5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Melanophilin a {ECO:0000313|Ensembl:ENSDARP00000107521, ECO:0000313|RefSeq:XP_005168770.1};
GN Name=mlpha {ECO:0000313|Ensembl:ENSDARP00000107521,
GN ECO:0000313|RefSeq:XP_005168770.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050208-724};
GN Synonyms=mlphb {ECO:0000313|RefSeq:XP_005168770.1}, si:ch211-186m12.3
GN {ECO:0000313|RefSeq:XP_005168770.1}, zgc:154096
GN {ECO:0000313|RefSeq:XP_005168770.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000107521};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000107521}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107521};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000107521, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107521};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005168770.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005168770.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX649631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005168770.1; XM_005168713.4.
DR PaxDb; 7955-ENSDARP00000107521; -.
DR Ensembl; ENSDART00000128940; ENSDARP00000107521; ENSDARG00000070991.
DR Ensembl; ENSDART00000128940.4; ENSDARP00000107521.1; ENSDARG00000070991.7.
DR GeneID; 561905; -.
DR AGR; ZFIN:ZDB-GENE-050208-724; -.
DR CTD; 561905; -.
DR ZFIN; ZDB-GENE-050208-724; mlpha.
DR eggNOG; ENOG502RJPZ; Eukaryota.
DR OrthoDB; 2967336at2759; -.
DR PhylomeDB; E7F2P6; -.
DR TreeFam; TF331599; -.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000070991; Expressed in swim bladder and 12 other cell types or tissues.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0017022; F:myosin binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0051876; P:pigment granule dispersal; IMP:ZFIN.
DR CDD; cd15752; FYVE_SlaC2-a; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR037442; Melanophilin_FYVE-rel_dom.
DR InterPro; IPR006788; Myrip/Melanophilin.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14555:SF1; MELANOPHILIN; 1.
DR PANTHER; PTHR14555; MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED; 1.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF04698; Rab_eff_C; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50916; RABBD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 4..124
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT REGION 369..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..56
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 453..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 369..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 60149 MW; A51AF83783A56959 CRC64;
MDKKLDLSRL SEEEAKHVWE VIQRDFVLRK KEEERLGELK TKIEKEEAKR ELLGSQSNLS
ESHCIRCLQP FKFLVNSRRQ CVDCKLFTCK TCSRYNKNEH GWVCDPCRMS RVLKIGTLGW
YHDNVHSRFK RFGSAKVMRS LYKRLNEEGH RDDDTQSMPD VRNAYNGHDE EHMDASEAQR
YKQMRKTKRL LSVHPMDLEI DDYAVHSRRQ SVQYIHDDRG QRNDLEYNSE IYHQHQQRMN
RRKSLDRFSR PDDGLYSENR MVRARSLSKI NSSMAPRQIY LDTSEEEDMY RYPVYQLPPR
RRSRASSQEN IQQGAPPINE LSKRMSAIES LLNRLEEKIT VPSDQPALPP AGHMEEEKLR
RKLDELMSDK GLSSDEEDPK RAPQYKRSTV RGDQTAMVLA SQEPLSSSSD EMPTEAQKVY
MTAGKSYEVA KKLQKIEHNA KNHYGGPLTD SELSELEDQV ALAVAKVQGT ESEVSDIESK
LAALSAKGLS IDKAKKKAVS MQQKRKFPQD FSSSRVHF
//
