ID E7F2R3_DANRE Unreviewed; 887 AA.
AC E7F2R3; A0A8N7T7Q7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Junctophilin-3-like {ECO:0000313|RefSeq:XP_693582.3};
DE SubName: Full=Si:ch211-146m13.3 {ECO:0000313|Ensembl:ENSDARP00000077277};
GN Name=jph3a {ECO:0000313|ZFIN:ZDB-GENE-110408-64};
GN Synonyms=si:ch211-146m13.3 {ECO:0000313|RefSeq:XP_693582.3};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000077277};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000077277}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000077277};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000077277, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000077277,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_693582.3}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_693582.3};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004163}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the junctophilin family.
CC {ECO:0000256|ARBA:ARBA00008599}.
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DR EMBL; AL929115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_693582.3; XM_688490.7.
DR STRING; 7955.ENSDARP00000077277; -.
DR PaxDb; 7955-ENSDARP00000077277; -.
DR Ensembl; ENSDART00000082842; ENSDARP00000077277; ENSDARG00000059534.
DR Ensembl; ENSDART00000082842.6; ENSDARP00000077277.5; ENSDARG00000059534.6.
DR GeneID; 565205; -.
DR KEGG; dre:565205; -.
DR AGR; ZFIN:ZDB-GENE-110408-64; -.
DR CTD; 565205; -.
DR ZFIN; ZDB-GENE-110408-64; jph3a.
DR eggNOG; KOG0231; Eukaryota.
DR HOGENOM; CLU_008078_2_0_1; -.
DR OMA; ANNWTDD; -.
DR OrthoDB; 5393283at2759; -.
DR PhylomeDB; E7F2R3; -.
DR TreeFam; TF317210; -.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000059534; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030314; C:junctional membrane complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IBA:GO_Central.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR InterPro; IPR017191; Junctophilin.
DR InterPro; IPR003409; MORN.
DR PANTHER; PTHR23085; GH28348P; 1.
DR PANTHER; PTHR23085:SF17; JUNCTOPHILIN-3-LIKE; 1.
DR Pfam; PF02493; MORN; 8.
DR SMART; SM00698; MORN; 6.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 866..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 168..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 355..382
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 425..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 98035 MW; 1266F0E2FC2ACB25 CRC64;
MSTGGRFDFD DGGSYCGGWE QGKAHGRGVC TGPQGQGEYA GAWSHGFEVL GVYTWPSGNS
YKGTWAQGKR HGIGVESKGR WEYKGEWTQG FKGRYGKLES TSSGSRYEGT WSNGLQDGYG
SETYSDGGTY QGQWLSGLRH GYGVRQSVPY GMAAIIFSPM CTSINSLRSD HSEGAPTPED
GSGVSGVSGS PVGRSGFVLC AHSEADRHRK RKGRFRQSIL SGLKLRRSES KSSLASQLSK
QSSFCSEAGM STVSSAASDI NSNVSLGEAE AGGSVDATVT ETYAGEWRND MRTGWGVSHR
SDGLHFEGEW FGNKRHGYGC TTFPDGTKEE GKYKQNVLVS GKRKNLIPLR TSKIREKVDR
ALEAAEKAAD IAKQKAEIAL SRMSHARGKA EAAEGVAQRA LEECRLARAI AKELSPSFHH
YGNGLECQRP KHHDRKEKDH EVVSTGTDSP ELCTPDTTPP VQTPDLSPVL SSPSSPPCSP
PTHRNRNACF MRQSAVDEQG GAEIQVLVEG RGIDSTRAGA NSWTAEMYPH RRGSKGESSR
STTPSLLEEE ISHINGHENS THHPWENGSS NHKPIEHMAP EKVWDQMSSN QKPWKHVSLN
QKTREHAISR EREREHKPSN HNSVDCESSK FKPQVHIYSN HKSAGHNNLS NHKTNEHAST
NHKPKEFISA HEKPHVSYHY NPQEHVSSYH KQHEHVHSNH KPRKSFTNHT IGEPSLNAYQ
LSDRGANNST LEWTVENNSQ WISSHSHPQE KEGENDYRVE MRFQPLDSLS QQNFGSGMKC
SGLQGHNLQR LRQRNQEGKE WGLAAREGSM DSVQMLDTLN VGVDVEEWPL HRDITLSPPL
TSSLEPLEHE GEQLNLMKTN SGSSSVLVVM VILLNIGVAI LFIHFFI
//
