ID E7FBR0_DANRE Unreviewed; 736 AA.
AC E7FBR0; A0A8M1PSA0;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Plakophilin 1b {ECO:0000313|Ensembl:ENSDARP00000069093};
DE SubName: Full=Plakophilin-1 {ECO:0000313|RefSeq:XP_001338299.2};
GN Name=pkp1b {ECO:0000313|Ensembl:ENSDARP00000069093,
GN ECO:0000313|RefSeq:XP_001338299.2,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-417};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000069093};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000069093}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000069093};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000069093, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000069093};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_001338299.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_001338299.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR EMBL; CR847929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001338299.2; XM_001338263.6.
DR STRING; 7955.ENSDARP00000069093; -.
DR PaxDb; 7955-ENSDARP00000069093; -.
DR Ensembl; ENSDART00000074605; ENSDARP00000069093; ENSDARG00000052705.
DR Ensembl; ENSDART00000074605.6; ENSDARP00000069093.5; ENSDARG00000052705.6.
DR GeneID; 797838; -.
DR KEGG; dre:797838; -.
DR AGR; ZFIN:ZDB-GENE-030131-417; -.
DR CTD; 797838; -.
DR ZFIN; ZDB-GENE-030131-417; pkp1b.
DR eggNOG; KOG1048; Eukaryota.
DR HOGENOM; CLU_009111_3_1_1; -.
DR OMA; SEPDLAW; -.
DR OrthoDB; 5473239at2759; -.
DR PhylomeDB; E7FBR0; -.
DR TreeFam; TF321877; -.
DR Reactome; R-DRE-351906; Apoptotic cleavage of cell adhesion proteins.
DR Reactome; R-DRE-6798695; Neutrophil degranulation.
DR Reactome; R-DRE-6805567; Keratinization.
DR Reactome; R-DRE-6809371; Formation of the cornified envelope.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000052705; Expressed in zone of skin and 20 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0045110; P:intermediate filament bundle assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372:SF3; PLAKOPHILIN-1; 1.
DR PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR Pfam; PF00514; Arm; 3.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7FBR0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT REPEAT 293..335
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 44..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 80322 MW; 02C1A6E7D3EF9DBA CRC64;
MMPEPLKSAL SLGNMEDTSL AVPSDIEHRS AQQRVLEQVH TIKKSKSKYR SKSKSVSALA
TSPTSPEGDS VFYDFKFSPG TSLSGPSFNR GGNMTNGAMQ RQNILRKSTN SRSSSGQQVN
SNSGRFDRSI YGFQGSVSTQ QKTSNQLYNK STRSAPDLGF QPTTNGMSST GQRSQTSRQT
FQRWEKGSQM PSSSYSNGTT LVRMSNSNQV NAVSRRPSSL QSNGESRMSM IRSGQAKDFS
GMTLEKPVSD MTMRDAVDCL SSTDENVQLC GASYIQHSTF NDDKAKQEVL TLKGLPLLVD
LLGSSSPQVQ ETVAAALRNA IFKNLPNKQE VQRSGGIKQA AQLLGDANTE TQKHLTGLLW
NLSSEDGLKP DLLRTALPAL TEKVIEPFSA NTVDNANTSL APEVFCNATA CLRNLSGSKL
ANRQSMRNCK GLIDSLMRYT ENCITAGMPD NQSLENCVCI LHNLTYQLET EMPTLFNKIN
ALASQSHNRS SSSDAGPIIC FRLQSQKLKQ RGFDYPVMED NNPEGVGWLF HSKALQFYLN
LLSSSERDAT LEACCGTLQN LTANEGIVSN FLSQTIVQKL NGMKFITPLL QSTNPALQNS
AVALLGNLSK SSQTNKVMAP QSLPQLVGFL NSGLSKKESS PEYDSAMATA LRSANTLINA
DPDTGKNLLN NSLINNLYNM SLNRDLQKSS KASALLLHNL WSNKNIQSFL KKNGMKKKSF
VNEVTSAAFK SHLVID
//
