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Database: UniProt
Entry: E7FFE9_DANRE
LinkDB: E7FFE9_DANRE
Original site: E7FFE9_DANRE 
ID   E7FFE9_DANRE            Unreviewed;       492 AA.
AC   E7FFE9;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   22-NOV-2017, entry version 65.
DE   SubName: Full=Potassium voltage-gated channel, shaker-related subfamily, member 1a {ECO:0000313|Ensembl:ENSDARP00000085980};
GN   Name=kcna1a {ECO:0000313|Ensembl:ENSDARP00000085980,
GN   ECO:0000313|ZFIN:ZDB-GENE-110408-15};
GN   Synonyms=si:ch73-333m22.1 {ECO:0000313|ZFIN:ZDB-GENE-110408-15};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000085980, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000085980}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000085980};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000124631}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124631};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000085980, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000085980,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000085980}.
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DR   EMBL; FO904916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005163101.1; XM_005163044.3.
DR   STRING; 7955.ENSDARP00000124631; -.
DR   Ensembl; ENSDART00000091547; ENSDARP00000085980; ENSDARG00000062942.
DR   Ensembl; ENSDART00000149335; ENSDARP00000124631; ENSDARG00000062942.
DR   GeneID; 795942; -.
DR   CTD; 795942; -.
DR   ZFIN; ZDB-GENE-110408-15; kcna1a.
DR   eggNOG; KOG1545; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00760000118846; -.
DR   OMA; DTYPPDH; -.
DR   OrthoDB; EOG091G10NU; -.
DR   TreeFam; TF313103; -.
DR   Reactome; R-DRE-1296072; Voltage gated Potassium channels.
DR   Proteomes; UP000000437; Chromosome 25.
DR   Bgee; ENSDARG00000062942; -.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003972; K_chnl_volt-dep_Kv1.
DR   InterPro; IPR004048; K_chnl_volt-dep_Kv1.1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01508; KV11CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   PRINTS; PR01496; SHAKERCHANEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT   TRANSMEM    166    186       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    216    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    384    405       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    134       BTB. {ECO:0000259|SMART:SM00225}.
SQ   SEQUENCE   492 AA;  55821 MW;  ABAAEF4469BCBAC6 CRC64;
     MTVVAGDNMD ETSAVPGHPQ DTYPPDHDDH ECCERVVINI AGLRFETQLK TLAQFPETLL
     GNPKKRMRYF DPLRNEYFFD RNRPSFDAIL YYYQSGGRLR RPANVPLDMF SEEIKFYELG
     VEAMEKFRED EGFIREEERP LPEKEFQRQI WLLFEHPESS GPARGIAIVS VMVILISIVI
     FCLETLPELK EDPEGRIKII GNTTYYYKPS ILADPFFIIE TLCIIWFSFE LIVRFFACPS
     KAAFFKNMMN TIDIVAIIPY FITLGTELAE EQDGKEGKGE QATSLAILRV IRLVRVFRIF
     KLSRHSKGLQ ILGQTLKASM RELGLLIFFL FIGVILFSSA VYFAEAEEKE SYFSSIPDAF
     WWAVVSMTTV GYGDMVPVTI GGKIVGSLCA IAGVLTIALP VPVIVSNFNY FYHRETEGEE
     QAQLLNVSNP NIASDSNSSR RSSSTVSKSE YMEIDGDINN SIDNFREANL RTGNCTIPNQ
     NCVNKSKLLT DV
//
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