ID E7FNU3_9LACO Unreviewed; 589 AA.
AC E7FNU3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=FbpA {ECO:0000313|EMBL:EFZ35346.1};
GN Synonyms=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=HMPREF0542_10570 {ECO:0000313|EMBL:EFZ35346.1};
OS Ligilactobacillus ruminis ATCC 25644.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=525362 {ECO:0000313|EMBL:EFZ35346.1, ECO:0000313|Proteomes:UP000004099};
RN [1] {ECO:0000313|EMBL:EFZ35346.1, ECO:0000313|Proteomes:UP000004099}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25644 {ECO:0000313|EMBL:EFZ35346.1,
RC ECO:0000313|Proteomes:UP000004099};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ35346.1}.
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DR EMBL; ACGS02000024; EFZ35346.1; -; Genomic_DNA.
DR AlphaFoldDB; E7FNU3; -.
DR HOGENOM; CLU_022481_2_1_9; -.
DR Proteomes; UP000004099; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.970.40; fibrinogen binding protein from staphylococcus aureus domain like; 1.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 470..559
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT COILED 315..342
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ SEQUENCE 589 AA; 67627 MW; 5A4B1D0FB818705F CRC64;
MTFFLPYLAK KVRILRNAFK EECEMAFDGL FTRAMVKELA DCLVGGRVAK ISAPYQNEVI
LTIRNQRKNY PLLLSAHPTY ARTQITEIPY SNPQTPTNFT MVLRKYLESA KLSFVEQFEN
DRVINFGFVT RNELGDKLPL LLSLEIMGRY SNLILVDQET GKIIDTVKHV SMDQNRYRTL
LPQATYRLPP SQGKINPFKD ESKAYLELLR KFPNREVLAK NIVKTYQGFS RESALILADR
LHETKELDDA FAAFLSETDN PHPTILETDK GLDFTCFKAS SEHVVTFETL SLMIDAYYRE
KATRDRVMSQ GSKLIHVIKN DLSRNRKKLV KLEKELKATE NADEYRIKGE LLTTYLYQIN
RGMTEVMLNN YYDHEKPVKI SLSNQLSPSA NAQKYFKRYQ KLKNAVSFVT RQIDLTKKEI
DYLETIQAQI ELAEPKDLQD IELELEKGGY LETKNKAKKK PRQAKSKPET FIASDGTEIS
VGKNNYQNDR LTLKTAKKDY YWLHVKNVPG SHVIVNSDSP SDETLTEAAI IAAYYSKSRA
SANVAVDFVQ VKKIRKPNGA KPGFVIYEGQ KTLYVTPDKE LIEKLKHAK
//
