ID E7FR11_9LACO Unreviewed; 750 AA.
AC E7FR11;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=DNA internalization competence protein ComEC/Rec2-like protein {ECO:0000313|EMBL:EFZ34398.1};
GN Name=comEC {ECO:0000313|EMBL:EFZ34398.1};
GN ORFNames=HMPREF0542_11338 {ECO:0000313|EMBL:EFZ34398.1};
OS Ligilactobacillus ruminis ATCC 25644.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=525362 {ECO:0000313|EMBL:EFZ34398.1, ECO:0000313|Proteomes:UP000004099};
RN [1] {ECO:0000313|EMBL:EFZ34398.1, ECO:0000313|Proteomes:UP000004099}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25644 {ECO:0000313|EMBL:EFZ34398.1,
RC ECO:0000313|Proteomes:UP000004099};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ34398.1}.
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DR EMBL; ACGS02000041; EFZ34398.1; -; Genomic_DNA.
DR AlphaFoldDB; E7FR11; -.
DR PATRIC; fig|525362.12.peg.386; -.
DR HOGENOM; CLU_010363_2_3_9; -.
DR Proteomes; UP000004099; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..691
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 750 AA; 85330 MW; 88E138E8FB88E1B2 CRC64;
MCLAATSFAI AGENRIWWVV LAFLIIRIIV LGNKRTLLLC LLSCFIFAVR FEQWQRNYQE
VIKNCQVNSA QHFLIYADKI AVDGNMMKCD AFWIEKREKL KLTAFLKNEE QQKELKSIDD
SFTIECQADI SPVNQPTNEN EFDYRKYCQS QNVFLSAFIK DWGSVQRVEN FQSFEPILFL
HDFRKKCALS FQKLPEPLDW YAMILLLGMR TDDLSDVYSS IKKLGLLYIF CLSGMHVFYL
SNFLCRFVQK FGIDYETGQL LNLIVLPCFV FVGGGSPSLI RAVMMNVLVI GCNRLLKIKL
TSLTAWSFVL LINLMSCPKL LMSFGTQLSY LLTLVIILQQ DENQIAASLK INLLSLPIIL
YQTYQWNLFT CLFSLMILPL FECMILPATV LGVIIPGHFL SRPCALILRT SSNFLQFLSR
LPGNIVFGKP SLTFVLMALF LAVMTETQKN GLKLWIVMFT CYCAMFLAIH FPLSSEIVYF
DIGQGDCTLI RSQFNREVIM IDTGGKVSFN TQEWQKRKGR TNGETIVANY LLSKGIKKID
RLYLTHQDAD HVANFPSISQ TIEIKQVIVP KGMENLESFK KRLEESTIGL ENVIGVTTQD
DGVDNDLRLL HPFESGQGTN DDSLVLWYDF NGIKCIFTGD LPQAGEKEVI TKYPEINADI
LKTGHHGSKT STSPEFVRKM NPRLAIISCG RNNRYGHPNQ ETLETLNNNG VPYLSTANCG
MIKLRKSFGE MPYLCVYGDG TASRLNLPLR
//
