ID E7FRR7_9LACO Unreviewed; 442 AA.
AC E7FRR7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Trypsin {ECO:0000313|EMBL:EFZ34199.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:EFZ34199.1};
GN Name=htrA {ECO:0000313|EMBL:EFZ34199.1};
GN ORFNames=HMPREF0542_11594 {ECO:0000313|EMBL:EFZ34199.1};
OS Ligilactobacillus ruminis ATCC 25644.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=525362 {ECO:0000313|EMBL:EFZ34199.1, ECO:0000313|Proteomes:UP000004099};
RN [1] {ECO:0000313|EMBL:EFZ34199.1, ECO:0000313|Proteomes:UP000004099}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25644 {ECO:0000313|EMBL:EFZ34199.1,
RC ECO:0000313|Proteomes:UP000004099};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ34199.1}.
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DR EMBL; ACGS02000044; EFZ34199.1; -; Genomic_DNA.
DR RefSeq; WP_003697683.1; NZ_GL833109.1.
DR AlphaFoldDB; E7FRR7; -.
DR PATRIC; fig|525362.12.peg.1198; -.
DR HOGENOM; CLU_020120_0_2_9; -.
DR Proteomes; UP000004099; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR43343; PEPTIDASE S12; 1.
DR PANTHER; PTHR43343:SF3; PROTEASE DO-LIKE 8, CHLOROPLASTIC; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EFZ34199.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 328..416
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 45900 MW; 158F81FDAABD3ECC CRC64;
MFDDNHNNQF DGEFNEVEPE NNSPESRDPK KGNGLGKVFV TALVAGLLGG GISVGGYVYY
QNHNSQVQDK IENSKGTTQT SNVKVNVGTQ ASKAFKKIKG AVVSVEAYSN SSSDSDTLED
LFGDSSSSET STSEGSGVIY KKDGNTAFVV TNNHVISGAN KVEVLLSSGK KVKASVVGHD
SVSDLAVLKI DASNVKQVAT FGNSDNINVG ETALAIGSPL GSEYATSLTQ GIISAKKRTI
DVTDSNGTST GQATVIQTDA AINPGNSGGP LINLAGQVIG INSMKLSSTG SSASSSSTSV
EGMGFAIPSN EVVSIINQLV QNGKVVRPAL GISLVDLDYV SEADRSQTLN LPSKVTSGVV
VMKVNSSSPL KKTDISKYDV IVSLGGKKVS GLSSLRTALY GHKVGDTVEI QYYHKGELKK
ANVKLTLEAN DKNTSTASNS GN
//
