ID E7FXP8_ERYRH Unreviewed; 1204 AA.
AC E7FXP8;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN Name=nanA2 {ECO:0000313|EMBL:EFY08272.1};
GN ORFNames=HMPREF0357_11425 {ECO:0000313|EMBL:EFY08272.1};
OS Erysipelothrix rhusiopathiae ATCC 19414.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Erysipelotrichaceae; Erysipelothrix.
OX NCBI_TaxID=525280 {ECO:0000313|EMBL:EFY08272.1, ECO:0000313|Proteomes:UP000003028};
RN [1] {ECO:0000313|EMBL:EFY08272.1, ECO:0000313|Proteomes:UP000003028}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19414 {ECO:0000313|EMBL:EFY08272.1,
RC ECO:0000313|Proteomes:UP000003028};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC {ECO:0000256|ARBA:ARBA00009348}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFY08272.1}.
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DR EMBL; ACLK02000003; EFY08272.1; -; Genomic_DNA.
DR AlphaFoldDB; E7FXP8; -.
DR STRING; 1648.A2I91_08040; -.
DR Proteomes; UP000003028; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.20.1270.90; AF1782-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR004124; Glyco_hydro_33_N.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR023364; Trans_sialidase_dom3.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13088; BNR_2; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02973; Sialidase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000313|EMBL:EFY08272.1};
KW Hydrolase {ECO:0000313|EMBL:EFY08272.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003028};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1181..1200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..219
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 355..416
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1119..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1204 AA; 133850 MW; 7B5651DB03616B70 CRC64;
MRGVFKLKKI SNIFVVLLTL VLGISLYPSS IFAMNDLNLN DLHLKGEGAD ISDHLSHIKE
FNQGSLTLRF RSESLSSDLT ALFSISNANL ENNYFALYYQ NSTGKLGIEF RDETGKHIIN
TSGTSTQLAN ANWHTVTVLN HGNRVEIYAD GILLASQDNI DFTKIQSLPW NRMKLGGVAR
LKGENLWPFS GKISSLNLTH DILDVDTIKT LHNDTASTVD PSTSEAIELY APGQDGSKNY
RIPSLLTTQD GTVLAAIDKR ITHQADWGNI DIAIRRSQDS GKTWSDTEVI IDLKSDPNVS
QENVNTNYQS SAFLIDAAMA QDNRNGRIYL LVDMFPESRG FFSVQNEDQD FGQPYVTKED
GTHIVLKGTD GKKYYAKADG TVFDLNTDII TNYRVVLESE KGMPFNDLGD LYEGDTYVGN
IYLKKSPLRI RQTAYLWLTH SDDDGQTWSS PHDITPQVKA DWMQFIGTGP GVGIQLKNGE
LAFPIYHTNR HGGNSQSTSM IKSADGITWH KTESLNDNRN FNGQVLNSKT LNNGGALVTE
SQVVQLNNGT LKQFARNVSG KVLVGTSYDN GETWENDLET LPITDVYSQM SALHYNHEGK
EYILLANPNG PKRTNGAVKL LQVLEGERLV LLSNTHMQSG NYEYNVVQPL PDGHFGLMYE
HKKPENGDNM SMMFKRFSFE DLGVKDTSSL SLDIQDTYLE IKSDKALIPS SNLTLTYNTT
QTTKPKRVDT NTLRFNLAEP VTILNGFTEG YLETLDGKAL NIANKQGLDE SLETLKALDF
ENLAPSVKDA ADQLITKAEL LSDNPFTIGD FIQQIHAMIG AIDPTYIPNS MFDVTASSQE
DEKGNTQVEG PIGLAFDGDP STFWHSKWGD KNPPFDVTVS FHHDMVVNAL TYLPRQDGTL
NGVVTEYQIL GKLGDAPLHV LNEGTLDTNL TKKIITFEDA HVDTLIFKVV KGLENYGNAA
EITLHGKTYR APLDYSSLNQ VLKTLENYNQ SLYTEASFKP LLELKEKAYE LLDNSETTQE
MIDEMVINLN EFINNLELSN YTLDSLRLKI QEVEDYMNTL DLALYTQTSV QAVYDALDSA
KALLQTPRFS FRSLFKASTP NEAQIKEAIE SLDSAVRGLS KREVETEEPS NPDENITPPI
VDPKPDTDSQ KPETPDSNTE DSAQISPTDK TDVTLPKTGQ AVSGFIGLGM LVSLCGFVIF
KRKQ
//
