ID   E7GP50_CLOSY            Unreviewed;       535 AA.
AC   E7GP50;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=Isopropylmalate/homocitrate/citramalate synthase {ECO:0000313|EMBL:EGA93430.1};
GN   ORFNames=HMPREF9474_02695 {ECO:0000313|EMBL:EGA93430.1};
OS   [Clostridium] symbiosum WAL-14163.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=742740 {ECO:0000313|EMBL:EGA93430.1, ECO:0000313|Proteomes:UP000002970};
RN   [1] {ECO:0000313|EMBL:EGA93430.1, ECO:0000313|Proteomes:UP000002970}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAL-14163 {ECO:0000313|EMBL:EGA93430.1,
RC   ECO:0000313|Proteomes:UP000002970};
RA   Earl A., Ward D., Feldgarden M., Gevers D., Finegold S.M., Summanen P.H.,
RA   Molitoris D.R., Vaisanen M.L., Daigneault M., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heilman E., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA   Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   White J., Yandava C., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Clostridium symbiosum strain WAL-14163.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGA93430.1}.
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DR   EMBL; ADLQ01000061; EGA93430.1; -; Genomic_DNA.
DR   RefSeq; WP_003501378.1; NZ_GL834311.1.
DR   AlphaFoldDB; E7GP50; -.
DR   STRING; 1512.GCA_900049235_02906; -.
DR   eggNOG; COG0119; Bacteria.
DR   HOGENOM; CLU_037512_0_0_9; -.
DR   Proteomes; UP000002970; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd07944; DRE_TIM_HOA_like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR10277:SF9; 2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR10277; HOMOCITRATE SYNTHASE-RELATED; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   4: Predicted;
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002970}.
FT   DOMAIN          4..247
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00682"
SQ   SEQUENCE   535 AA;  61202 MW;  79118519B247CC5F CRC64;
     MKEIKLLDCT LRDGGFVNDW EFGYGNIINI FERLISSGVD VLEIGFLDDR RPFDKNRTIM
     PDTKSADDIF GRLDKGNAMI VAMIDYGTCR IENLAPCAES FIDGIRVIFK KHVMKEAIAY
     CREVKQLGYQ VYVQAVSITS YSDREILDLI ELVNELNPYA LSIVDTYGLL HQENLMHYFE
     LFNHNLNREI GIGYHSHNNF QLAYSNSIEV LRETADRRVL IDASLYGMGK SAGNLPLELI
     SMYMNTSCGR NFNTAQMLEA IDINIMPFFR KSPWGYNLFF YISASNNCHP SYVKFLMDKQ
     TLSLKALNGI LDSIEPEKKL LYDKDYIEQL YRTYQSTECN DETELAELTK SLAGKALLLL
     GPGKNMELQK DRVLSYIEKT NPVIISVNYI PDDIAIDYAF LSNSRRYVQL GSRLLELKDR
     TDRKVKVIAT SNVTNVKDRF DYTLNYSSLI DPNAEIIDNS FVMLLNVLVK TGVSHAACAG
     FDGYTYHGDN YFNADMDYRI AREKSQGINQ YVTETLDRLA GTLNVEFITD SRYHK
//