ID E7GQH9_CLOSY Unreviewed; 600 AA.
AC E7GQH9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Muramidase {ECO:0000313|EMBL:EGA93026.1};
GN ORFNames=HMPREF9474_03174 {ECO:0000313|EMBL:EGA93026.1};
OS [Clostridium] symbiosum WAL-14163.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=742740 {ECO:0000313|EMBL:EGA93026.1, ECO:0000313|Proteomes:UP000002970};
RN [1] {ECO:0000313|EMBL:EGA93026.1, ECO:0000313|Proteomes:UP000002970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAL-14163 {ECO:0000313|EMBL:EGA93026.1,
RC ECO:0000313|Proteomes:UP000002970};
RA Earl A., Ward D., Feldgarden M., Gevers D., Finegold S.M., Summanen P.H.,
RA Molitoris D.R., Vaisanen M.L., Daigneault M., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heilman E., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA White J., Yandava C., Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium symbiosum strain WAL-14163.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endohydrolysis of the di-N-acetylchitobiosyl unit in high-
CC mannose glycopeptides and glycoproteins containing the
CC -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue
CC remains attached to the protein; the rest of the oligosaccharide is
CC released intact. Cleaves the peptidoglycan connecting the daughter
CC cells at the end of the cell division cycle, resulting in the
CC separation of the two newly divided cells. Acts as an autolysin in
CC penicillin-induced lysis. {ECO:0000256|ARBA:ARBA00043889}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGA93026.1}.
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DR EMBL; ADLQ01000071; EGA93026.1; -; Genomic_DNA.
DR RefSeq; WP_003502324.1; NZ_GL834313.1.
DR AlphaFoldDB; E7GQH9; -.
DR STRING; 1512.GCA_900049235_03430; -.
DR eggNOG; COG1705; Bacteria.
DR eggNOG; COG5632; Bacteria.
DR HOGENOM; CLU_042024_3_0_9; -.
DR Proteomes; UP000002970; Unassembled WGS sequence.
DR GO; GO:0004040; F:amidase activity; IEA:InterPro.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR Gene3D; 1.10.530.10; -; 1.
DR Gene3D; 3.40.80.10; Peptidoglycan recognition protein-like; 1.
DR InterPro; IPR036505; Amidase/PGRP_sf.
DR InterPro; IPR002502; Amidase_domain.
DR InterPro; IPR002901; MGlyc_endo_b_GlcNAc-like_dom.
DR PANTHER; PTHR33308; PEPTIDOGLYCAN HYDROLASE FLGJ; 1.
DR PANTHER; PTHR33308:SF9; PEPTIDOGLYCAN HYDROLASE FLGJ; 1.
DR Pfam; PF01510; Amidase_2; 1.
DR Pfam; PF01832; Glucosaminidase; 1.
DR SMART; SM00047; LYZ2; 1.
DR SUPFAM; SSF55846; N-acetylmuramoyl-L-alanine amidase-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002970}.
FT DOMAIN 3..164
FT /note="Mannosyl-glycoprotein endo-beta-N-
FT acetylglucosamidase-like"
FT /evidence="ECO:0000259|SMART:SM00047"
FT REGION 372..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 66627 MW; CC5C2E1BC31AADAD CRC64;
MKEQDFIQKI CGYAISDMKE NGILASVTIA QAILESSWGT SELAKKANNY FGMKCSLSSN
SWGSVWDRVS KYTKVTNEQD EAGKIYTIKA DFRAYPDIEM SIKDHSMYLV GAMNGTEHRY
CGIANEKDYR KAVEIIKAGG YATDINYVSK ICSIIKKYEL TQYDEMEELN MGIEIRKQIA
TNSPCNKTGD EITVKGSMLH SVGCPQPKPE VFAKIWETST GACVHAVTGA DAYAIQCLPL
FPERKKARRG WHGASGKNGS VNNTHLSLEM TEPATIKYVG GATWIETGDG SNTKRHVLAT
YANAVKLFAE WCSEFGLNPL EDGVIISHHE GNQRGIASNH GDVEHIWNKF GLTMNQFRQD
VNKAMRGQVV DTVPTTPVDN SSDDKSSQSV NPLSGTVTVI YEGDDGLNVR KAPSITADVD
QIVYNGVYTV VGISADEKWY KLKSGLFITT IPEYVSFKAT PEQKQQTAGT GYYRVRKSWN
DAGSQIGAFK NQNNAIELCK QNSGYKVFDN DGNEIYPCIK DDGTPFKFRV TIPDLRIRKG
PGTTYDYWKK NGSPEYTGKN VFTIIDTAEG PGAKIWGLLK SGEKDRDRWI SLDEDYGNRL
//
