ID E7N670_9ACTO Unreviewed; 497 AA.
AC E7N670;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=CoA-acylating methylmalonate-semialdehyde dehydrogenase {ECO:0000313|EMBL:QCT32676.1};
DE SubName: Full=Methylmalonate-semialdehyde dehydrogenase (Acylating) {ECO:0000313|EMBL:EFW28312.1};
DE EC=1.2.1.27 {ECO:0000313|EMBL:EFW28312.1};
GN Name=mmsA {ECO:0000313|EMBL:EFW28312.1};
GN ORFNames=FBF36_03645 {ECO:0000313|EMBL:QCT32676.1}, HMPREF9057_00270
GN {ECO:0000313|EMBL:EFW28312.1};
OS Actinomyces sp. oral taxon 171 str. F0337.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=706439 {ECO:0000313|EMBL:EFW28312.1, ECO:0000313|Proteomes:UP000005722};
RN [1] {ECO:0000313|EMBL:EFW28312.1, ECO:0000313|Proteomes:UP000005722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0337 {ECO:0000313|EMBL:EFW28312.1,
RC ECO:0000313|Proteomes:UP000005722};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QCT32676.1, ECO:0000313|Proteomes:UP000310751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0337 {ECO:0000313|EMBL:QCT32676.1,
RC ECO:0000313|Proteomes:UP000310751};
RA Collins A.J., Murugkar P., Chen T., Dewhirst F.E.;
RT "Saccharibacteria TM7 and host bacteria genomes.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AECW01000031; EFW28312.1; -; Genomic_DNA.
DR EMBL; CP040005; QCT32676.1; -; Genomic_DNA.
DR RefSeq; WP_009393466.1; NZ_GL637702.1.
DR AlphaFoldDB; E7N670; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_10_11; -.
DR Proteomes; UP000005722; Unassembled WGS sequence.
DR Proteomes; UP000310751; Chromosome.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EFW28312.1}.
FT DOMAIN 17..477
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 497 AA; 53245 MW; 085264CBBC0457C3 CRC64;
MRTIAHWVDG KYYEGNPIGR FAVENPGTGE VEAELLQASD ADLDHAVEVA RRAQKEWAKV
SLAKRTAIMF RMRQLVLDHQ DEMAKMIVAE HGKNYSDAVG EIQRGRETLD FATAINLALK
GEHSFDISTG VDIHTLRQPV GVVAGICPFN FPAMVPMWMH PIAIATGNAF VLKPASATPS
AALLTAELYK EAGLPDGVFN VVSGNRTMVS KVLEHPGIDA ISFVGSTPVA HIVQDTGVTH
GKRVQALGGA NNHAIVMPDS DLDFAAQHIS AAAFGAAGER CMALPVVVAV GGCGPDLARR
VKAHAEKIKV GYGMDEGVEM GPVIDAKSKE FITGLIDDAE AKGAEVVLDG RPLVIPGHEK
GHFLGPTIVD NVSLESSLYT EEVFGPVLAI VHADTYEEAI KQVNSSPFGN GAAIFTNDGG
VARRFELDVE AGMVGINVPI PTPVAYYSFG GWKESLLGDT HIHGPEGVRF YTRAKAVTTR
WPSEKTYAAT MSFQREE
//
