ID E7NXY7_TREPH Unreviewed; 726 AA.
AC E7NXY7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=HAMP domain protein {ECO:0000313|EMBL:EFW36551.1};
GN ORFNames=HMPREF9554_02957 {ECO:0000313|EMBL:EFW36551.1};
OS Treponema phagedenis F0421.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=754027 {ECO:0000313|EMBL:EFW36551.1, ECO:0000313|Proteomes:UP000004157};
RN [1] {ECO:0000313|EMBL:EFW36551.1, ECO:0000313|Proteomes:UP000004157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0421 {ECO:0000313|EMBL:EFW36551.1,
RC ECO:0000313|Proteomes:UP000004157};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000256|ARBA:ARBA00029447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFW36551.1}.
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DR EMBL; AEFH01000250; EFW36551.1; -; Genomic_DNA.
DR RefSeq; WP_002701165.1; NZ_GL638118.1.
DR AlphaFoldDB; E7NXY7; -.
DR STRING; 162.TPHV1_500003; -.
DR eggNOG; COG0840; Bacteria.
DR HOGENOM; CLU_000445_107_19_12; -.
DR Proteomes; UP000004157; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd12913; PDC1_MCP_like; 1.
DR CDD; cd18774; PDC2_HK_sensor; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00283; MA; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW ProRule:PRU00284};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 315..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 339..393
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 440..662
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000259|PROSITE:PS50111"
FT COILED 441..468
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 726 AA; 80730 MW; DE9E8620B2C51E13 CRC64;
MKFTIRKKLV LTLLGVFSPF ALIIFIFLIT GLTRASYDFA LQHLYDQSMT MARDVQLIIQ
NVYDRTVSLA RTFENYTIIP ADLRREYFNR LQQTTLSEKN NFVDVWTVWE PNALDGLDNK
FKNQPGHDET GRFIPYWTKV NGIVSLNPLT DYDGSFWYEN PLHSKVGILI KPNRYTLQGK
TMYVAGSAVP IHDKNGKPIG VIGIDYSLSH MQDLFKTETV FNKGAPILVS AEGLVLFHKD
DSLVSKELPE FSESDFSVFF KKAAEDLKPF HFVKKIDDAK WMYVYVPIKI GETKQIWFAG
SALPVFDIYA NGIKLTIAVI IMLAITAVTV FILLFLLIYK ITKRIEQVTN SLYDIAEGEG
DLTVHLPVTG NDEIADLATF FNETIKKIRS AVVTVGKAAG NLQKVGTDLS DNMNETTGAI
SQIGENIKEV KRQVLSQASS VNQTEASMQE MRKIIENLNR HIEMQAANIT ESSSAITEMV
VNINSVSSIL SENAKRIETL QEKSNYVRAK TVNSARLTQE IAQESEGLLQ ASTVIQHIAS
QTNLLAMNAA IEAAHAGNAG KGFAVVADEI RKLAEQSSTQ GKQISSVLKT LKIKIDDIAS
DAAEAQKLFD DTYSLTQEVK TQEDSIMNAM QEQSSGSEQV IKTIIDIGEI TSKVRSGSVD
MMNGSIQVAD EIQRLTHIAG QITTSMDEMD LGAIQINKAT QKLNEITQQT KETIENLAIE
VGKFKV
//
