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Database: UniProt
Entry: E7Q9E9_YEASB
LinkDB: E7Q9E9_YEASB
Original site: E7Q9E9_YEASB 
ID   E7Q9E9_YEASB            Unreviewed;       840 AA.
AC   E7Q9E9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   25-APR-2018, entry version 18.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=FOSTERSB_4553 {ECO:0000313|EMBL:EGA56784.1};
OS   Saccharomyces cerevisiae (strain FostersB) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=764102 {ECO:0000313|EMBL:EGA56784.1, ECO:0000313|Proteomes:UP000000309};
RN   [1] {ECO:0000313|EMBL:EGA56784.1, ECO:0000313|Proteomes:UP000000309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FostersB {ECO:0000313|EMBL:EGA56784.1,
RC   ECO:0000313|Proteomes:UP000000309};
RX   PubMed=21304888; DOI=10.1371/journal.pgen.1001287;
RA   Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA   Pretorius I.S., Egholm M., Chambers P.J.;
RT   "Whole-genome comparison reveals novel genetic elements that
RT   characterize the genome of industrial strains of Saccharomyces
RT   cerevisiae.";
RL   PLoS Genet. 7:E1001287-E1001287(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGA56784.1}.
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DR   EMBL; AEHH01000073; EGA56784.1; -; Genomic_DNA.
DR   EnsemblFungi; EGA56784; EGA56784; FOSTERSB_4553.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000000309; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000309};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000309};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    417    441       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    462    479       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    539    561       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    573    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    633    651       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    736    759       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    765    788       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   840 AA;  95591 MW;  158569B146004774 CRC64;
     MAEKEEAIFR SAEMALVQFY IPQEISRDSA YTLGQLGLVQ FRDLNSKVRA FQRTFVNEIR
     RLDNVERQYR YFYSLLKKHD IKLYEGDTDK YLDGSGELYV PPSGSVIDDY VRNASYLEER
     LIQMEDATDQ IEVQKNDLEQ YRFILQSGDE FFLKGDNTDS TSYMDEDMID ANGENIAAAI
     GASVNYVTGV IARDKVATLE QILWRVLRGN LFFKTVEIEQ PVYDVKTREY KHKNAFIVFS
     HGDLIIKRIR KIAESLEANL YDVDSSNEGR SQQLAKVNKN LSDLYTVLKT TXTTLESELY
     AIAKELDSWF QDVTREKAIF EILNKSNYDT NRKILIAEGW IPRDELATLQ ARLGEMIARL
     GIDVPSIIQV LDTNHTPPTF HRTNKFTAGF QSICDCYGIA QYREINAGLP TIVTFPFMFA
     IMFGDMGHGF LMTLAALSLV LNEKKINKMK RGEIFDMAFT GRYIILLMGV FSMYTGFLYN
     DIFSKTMTIF KSGWKWPDHW KKGESITATS VGTYPIGLDW AWHGTENALL FSNSYKMKLS
     ILMGFIHMTY SYFFSLANHL YFNSMIDIIG NFIPGLLFMQ GIFGYLSVCI VYKWAVDWVK
     DGKPAPGLLN MLINMFLSPG TIDDELYPHQ AKVQVFLLLM ALVCIPWLLL VKPLHFKFTH
     KKKSHEPLPS TEADASXEDL EAQQLISAMD ADDAEEEEVG SGSHGEDFGD IMIHQVIHTI
     EFCLNCVSHT ASYLRLWALS LAHAQLSSVL WTMTIQIAFG FRGFVGVFMT VALFAMWFAL
     TCAVLVLMEG TSAMLHSLRL HWVESMSKFF VGEGLPYEPF AFEYKDMEVA VASASSSASS
//
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