ID E7REV3_9BACL Unreviewed; 794 AA.
AC E7REV3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/isomerase family protein {ECO:0000313|EMBL:EGA90489.1};
GN ORFNames=GPDM_04964 {ECO:0000313|EMBL:EGA90489.1};
OS Planococcus donghaensis MPA1U2.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Planococcus.
OX NCBI_TaxID=933115 {ECO:0000313|EMBL:EGA90489.1, ECO:0000313|Proteomes:UP000003052};
RN [1] {ECO:0000313|EMBL:EGA90489.1, ECO:0000313|Proteomes:UP000003052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MPA1U2 {ECO:0000313|EMBL:EGA90489.1,
RC ECO:0000313|Proteomes:UP000003052};
RX PubMed=21994932; DOI=10.1128/JB.05983-11;
RA Pearson M.D., Noller H.F.;
RT "The Draft Genome of Planococcus donghaensis MPA1U2 Reveals Nonsporulation
RT Pathways Controlled by a Conserved Spo0A Regulon.";
RL J. Bacteriol. 193:6106-6106(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGA90489.1}.
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DR EMBL; AEPB01000017; EGA90489.1; -; Genomic_DNA.
DR RefSeq; WP_008429519.1; NZ_AEPB01000017.1.
DR AlphaFoldDB; E7REV3; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000003052; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Isomerase {ECO:0000313|EMBL:EGA90489.1};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..305
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 794 AA; 87330 MW; 0C85A49FA8562EE8 CRC64;
MAYQIRKAAV LGSGVMGSGI AAHLANIGIP VMLLDIVPRE LSKEEQAKGL TLEDKVVRNR
MATGSIQKLL KQKPAPLTAK KNLQLITPGN LEDDLEKLKD VDWIIEVIVE NLDIKKSLYE
KIDGVRKEGT IISSNTSGIS INAMVEGRSE DFGKHFLGTH FFNPPRYLKL LEIIPAKTTA
PEVLEFMSTF GEDQLGKGVV VAKDTPNFIA NRIGTYGLLV TLREMMARNY SIGEVDSVTG
PLIGRPKSAT FRTLDVVGLD TFMHVSKNVY DQTSGEEQKV FDAPEFMKKM VENGWLGAKS
GQGFFLKKDK EILELDPETL EYRPAGKLKT PSQEMAKQQK GLAAKMKKLV YAEDRTGELL
WSILSPTLRY SAELNGEIAD DIVAIDNAMK WGFGWQQGPF ETWDAIGVKK SVEKMTQEGH
AVPAFVQALI DSGNENFYKE QDGDLHFFDG TTYQPVPANE KVIDLKRYKK KHGVIKSNSG
ASLIDLGDGI ALLEFHSRSN AIGLDIMQMI NFAVDEVDKN YKGLVIGNQG KNFCVGANLG
MILMEAQDDN IFELDFTIKT FQNAMMKLKY SNKPVVAAPF GMSLGGGAEV TLPAAHIQAS
METYMGLVEV GVGLIPGGGG NKELYMKQLK GLPNGVTIDY LNIATKVFES IAMAKVSTSA
EEARENNFLN FVDGISVNSD HLLYDAKQAA LSLYENGYQA PLREKVPVPG EPGYATLLLG
AEGMFISGYI SEHDLKIAKK LAFVLAGGKV PYGTKVDEQY LLDLERQAFL SLVAEPKTQQ
RMQHMLVKGK PLRN
//
