ID E7RQY1_9BACT Unreviewed; 435 AA.
AC E7RQY1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Alpha-L-fucosidase {ECO:0000313|EMBL:EFZ36669.1};
DE EC=3.2.1.51 {ECO:0000313|EMBL:EFZ36669.1};
GN Name=fucA2 {ECO:0000313|EMBL:EFZ36669.1};
GN ORFNames=HMPREF0663_11582 {ECO:0000313|EMBL:EFZ36669.1};
OS Hoylesella oralis ATCC 33269.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Hoylesella.
OX NCBI_TaxID=873533 {ECO:0000313|EMBL:EFZ36669.1, ECO:0000313|Proteomes:UP000005580};
RN [1] {ECO:0000313|EMBL:EFZ36669.1, ECO:0000313|Proteomes:UP000005580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33269 {ECO:0000313|EMBL:EFZ36669.1,
RC ECO:0000313|Proteomes:UP000005580};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-
CC 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the
CC carbohydrate moieties of glycoproteins.
CC {ECO:0000256|ARBA:ARBA00004071}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ36669.1}.
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DR EMBL; AEPE02000005; EFZ36669.1; -; Genomic_DNA.
DR RefSeq; WP_004369737.1; NZ_GL833119.1.
DR AlphaFoldDB; E7RQY1; -.
DR STRING; 28134.SAMN05444288_2392; -.
DR eggNOG; COG3669; Bacteria.
DR HOGENOM; CLU_002934_0_3_10; -.
DR Proteomes; UP000005580; Unassembled WGS sequence.
DR GO; GO:0004560; F:alpha-L-fucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006004; P:fucose metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR016286; FUC_metazoa-typ.
DR InterPro; IPR000933; Glyco_hydro_29.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10030; ALPHA-L-FUCOSIDASE; 1.
DR PANTHER; PTHR10030:SF46; ALPHA-L-FUCOSIDASE-RELATED; 1.
DR Pfam; PF01120; Alpha_L_fucos; 1.
DR PIRSF; PIRSF001092; Alpha-L-fucosidase; 1.
DR PRINTS; PR00741; GLHYDRLASE29.
DR SMART; SM00812; Alpha_L_fucos; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000313|EMBL:EFZ36669.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EFZ36669.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005580};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..435
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003224155"
FT SITE 280
FT /note="May be important for catalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR001092-1"
SQ SEQUENCE 435 AA; 49102 MW; 16A03C01D0DBE66F CRC64;
MKKFIPTIVV LLMSIAGGAQ NGYLPATGNI DARNKFQDNK FGIFLHWGIY SMLGEGEWVM
NNRNINYIEY SKLAGGFYPS KFNADEWVKA IKTAGAKYIT ITARHHDGFS MFGTKSDGYN
IVDATPFGRD VLKELATACR REGISLHFYY SHLDWHRLDY PLGRTGRWLG RPANRQDWRS
YYAFMNKQLT ELLTGYGPIG AIWFDGFWDH DSDDKPFDWQ LGKQYELIHK LQPACLIGNN
HHEVPFEGED IQIFERDLPG ENKAGYSGKN GISALPLETC ETMSRCWGYN ITDSLYKTSK
ELIHLIVRAA GRNANLLLNI GPQPDGQLPA AAAQRLGEIG KWMSTYGETI YGTRGGIIAP
HEWGVSTQKG NKLYVHILNL QDKGLFLPVD NSKITNAVMF NNHTKVNFTR SKYGITIELP
SVPKDIDCVV ELTVK
//
