ID E7SAF2_9STRE Unreviewed; 729 AA.
AC E7SAF2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Arylsulfatase {ECO:0000313|EMBL:EFV99061.1};
DE EC=3.1.6.- {ECO:0000313|EMBL:EFV99061.1};
GN ORFNames=HMPREF9421_1169 {ECO:0000313|EMBL:EFV99061.1};
OS Streptococcus australis ATCC 700641.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888833 {ECO:0000313|EMBL:EFV99061.1, ECO:0000313|Proteomes:UP000002814};
RN [1] {ECO:0000313|EMBL:EFV99061.1, ECO:0000313|Proteomes:UP000002814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700641 {ECO:0000313|EMBL:EFV99061.1,
RC ECO:0000313|Proteomes:UP000002814};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004936}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LTA synthase family.
CC {ECO:0000256|ARBA:ARBA00009983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV99061.1}.
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DR EMBL; AEQR01000019; EFV99061.1; -; Genomic_DNA.
DR RefSeq; WP_006596073.1; NZ_GL636091.1.
DR AlphaFoldDB; E7SAF2; -.
DR PATRIC; fig|888833.12.peg.947; -.
DR eggNOG; COG1368; Bacteria.
DR HOGENOM; CLU_021310_0_0_9; -.
DR Proteomes; UP000002814; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16015; LTA_synthase; 1.
DR Gene3D; 3.30.1120.170; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:EFV99061.1};
KW Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002814};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 254..557
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT REGION 692..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 310
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT BINDING 262
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 310
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 428
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT BINDING 489
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 490
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ SEQUENCE 729 AA; 82720 MW; D811AC6D4B6DC4F9 CRC64;
MKKITKTILD AMSTRLGFVF TLLMLYWFKT MWAYTVDFNL DIQGFYQVFL AVINPIPLSL
LFIGLAFYIK RTKLFYLLSF SIYVILFIWL ISNSIYYREF TDFVTVNTML ASSKVSAGLG
AAALELFRPW DIIYVLDFPI LAFLFLKKLV KLDPRPFNKR ASFAVTSLSA MLFSANLFLA
EIDRPELLTR GFSNYYVVRA LGLPAFLGYS ANQTYMANKE RSKASEVDLK PVEEYVASHY
AQPNPETFGL AKGRNVIYIH LESFQQFLID YKLKVDDKEY EVTPFINSLY HSNETFAFAN
VFNQVKAGKT SDAETMIETG LFGLNQGSFM VNYGGTNTQQ AAPFILSKNG YQSSAVFHGN
AGSFWNRNTA YKQWGYHYFF DASYFTKQDD TNSFQYGLND KIMLKDSIKY LEHMQQPFYT
KFITVSNHYP YTTSLIGDEI GFPLAETQDE TINGYFATAN YLDSSIKAFF DYLKASGLYE
NSIIVLYGDH YGISNSRNPA LAPLLDKNSE TWSSYDNAML QRVPYMVVIP GMNKGKVIET
YGGEIDMLPT LEHLLGIDSK NFLQVGQDLL SPDHSQIVAF RSSNYFVTPE YTSYSGRTYY
TKTGEEITNP DETTKEQLDK IREAANLQLK ISDSIQTGDL LRFYTGNNLG KVNPDDYSYN
NSMKALKKIE KEKGDASTSL YSQKGNQSTV DLFKAPSYKE LHPEQFSSSS SSSEDSSSSS
STSSSSEKK
//
