ID E8JTS9_STRCR Unreviewed; 368 AA.
AC E8JTS9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:EFX53354.1};
DE EC=1.3.1.12 {ECO:0000313|EMBL:EFX53354.1};
GN Name=tyrA {ECO:0000313|EMBL:EFX53354.1};
GN ORFNames=HMPREF9422_0709 {ECO:0000313|EMBL:EFX53354.1};
OS Streptococcus cristatus ATCC 51100.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=889201 {ECO:0000313|EMBL:EFX53354.1, ECO:0000313|Proteomes:UP000002829};
RN [1] {ECO:0000313|EMBL:EFX53354.1, ECO:0000313|Proteomes:UP000002829}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51100 {ECO:0000313|EMBL:EFX53354.1,
RC ECO:0000313|Proteomes:UP000002829};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX53354.1}.
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DR EMBL; AEVC01000007; EFX53354.1; -; Genomic_DNA.
DR RefSeq; WP_005590556.1; NZ_LS483383.1.
DR AlphaFoldDB; E8JTS9; -.
DR GeneID; 48423196; -.
DR PATRIC; fig|889201.11.peg.106; -.
DR eggNOG; COG0287; Bacteria.
DR HOGENOM; CLU_055968_2_1_9; -.
DR Proteomes; UP000002829; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EFX53354.1}.
FT DOMAIN 4..294
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 368 AA; 40862 MW; 4C5A29DBAECAF3DB CRC64;
MERKTVYIAG LGLIGASLAL GIRRAHPEIE ILGYNRSEES RRVALERGMV DRVTADFAAF
APLADVIILA VPIKQTIAFI KNLAELDLKG NVIISDAGST KAEIVAAAEK YLQNKPVRFV
GAHPMAGSHK TGAKAAHVTL FENAYYIFTP SSLTKPGTIE EMKDLLGGLH ARFIQADAAE
HDRVTSQISH FPHILASSLM EQAAAYSQEH ELTQSFAAGG FRDMTRIAES EPGMWTSILL
TNPQAILERL EDFKDQLDKV AAAIEAKDET AIWEFFDRGR QSRKQMEIHK RAGVDSFYDL
FIEVPDEEDA ILGILELLRG ISVVNIRINE ENREDINGIL QITFKNRQDL EKSAKIVKEN
TDYLVSVD
//
