ID E8JVZ0_STRCR Unreviewed; 305 AA.
AC E8JVZ0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Putative N-acetylneuraminate lyase {ECO:0000313|EMBL:EFX52529.1};
DE EC=4.1.3.3 {ECO:0000313|EMBL:EFX52529.1};
GN Name=nanH {ECO:0000313|EMBL:EFX52529.1};
GN ORFNames=HMPREF9422_1370 {ECO:0000313|EMBL:EFX52529.1};
OS Streptococcus cristatus ATCC 51100.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=889201 {ECO:0000313|EMBL:EFX52529.1, ECO:0000313|Proteomes:UP000002829};
RN [1] {ECO:0000313|EMBL:EFX52529.1, ECO:0000313|Proteomes:UP000002829}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51100 {ECO:0000313|EMBL:EFX52529.1,
RC ECO:0000313|Proteomes:UP000002829};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX52529.1}.
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DR EMBL; AEVC01000021; EFX52529.1; -; Genomic_DNA.
DR RefSeq; WP_005591324.1; NZ_LS483383.1.
DR AlphaFoldDB; E8JVZ0; -.
DR GeneID; 48422523; -.
DR PATRIC; fig|889201.11.peg.1760; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_6_0_9; -.
DR Proteomes; UP000002829; Unassembled WGS sequence.
DR GO; GO:0008747; F:N-acetylneuraminate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR42849; N-ACETYLNEURAMINATE LYASE; 1.
DR PANTHER; PTHR42849:SF1; N-ACETYLNEURAMINATE LYASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT ACT_SITE 139
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 167
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 209
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 305 AA; 33135 MW; D084272A3E4CBE03 CRC64;
MSDLKKYEGV IPAFYACYDE EGEISPERTR ALVEYFIDKG VQGLYVNGSS GECIYQSVAD
RKVILEEVMK VAKGKLTIIA HVACNNTKDS IELAKHAEAL GVDAIAAIPP IYFRLPEYSV
AQYWNDISAA APHTDFVIYN IPQLAGAALT PSLYKEMLKN ERVIGVKNSS MPVQDIQTFA
ALGGSDHLVF NGPDEQFLGG RLMGAAAGIG GTYGAMPELF LKLNQLIADK ELERAKELQF
AINDIIGKLT SAHGNMYAVI KEVLKLNEGL AIGSVRAPLT PVVEADRPVV EAAAALIQET
KERFL
//
