ID E8K2L0_9STRE Unreviewed; 844 AA.
AC E8K2L0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:EFX35855.1};
GN ORFNames=HMPREF9423_1723 {ECO:0000313|EMBL:EFX35855.1};
OS Streptococcus infantis ATCC 700779.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=889204 {ECO:0000313|EMBL:EFX35855.1, ECO:0000313|Proteomes:UP000002815};
RN [1] {ECO:0000313|EMBL:EFX35855.1, ECO:0000313|Proteomes:UP000002815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700779 {ECO:0000313|EMBL:EFX35855.1,
RC ECO:0000313|Proteomes:UP000002815};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX35855.1}.
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DR EMBL; AEVD01000017; EFX35855.1; -; Genomic_DNA.
DR RefSeq; WP_006149352.1; NZ_GL732439.1.
DR AlphaFoldDB; E8K2L0; -.
DR GeneID; 29747731; -.
DR PATRIC; fig|889204.5.peg.1856; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_9; -.
DR Proteomes; UP000002815; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000002815}.
FT DOMAIN 676..692
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 602..609
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 844 AA; 94880 MW; 272A97885169C175 CRC64;
MTTEKLSPGM QQYVDIKKQY PDAFLLFRMG DFYELFYEDA VNAAQILEIS LTSRNKNAEN
PIPMAGVPYH SAQQYIDVLV ERGYKVAIAE QMEDPKQAVG VVKREVVQVI TPGTVVDSSK
PDSHNNFLVA IDREGSQYGL AYMDLVTGDF YVTGLSDFSL VCGEIRNLKA REVVIGYDLS
EAEEQILSRQ MNLVLSYEQE TYEDVHLLDS RLATVEGAAS GKLLQYVHRT QMRELNHLKP
VIRYEIKDFL QMDFATKASL DLVENARSGK KQGSLFWLLD ETKTAMGMRL LRSWIQRPLI
DLDRIIERQE VVQVFLDYFF ERSDLTESLK GVYDIERLAS RVSFGKSNPK DLLQLATTLG
SVPRIRAILE GMEQPALAYL IEQLDAIPEL ENLISAAIAP EAPHVITEGG IIRTGFDETL
DKYRRVLREG TSWIAEIEAK ERENSGINTL KIDYNKKDGY YFHVTNSQLG NVPAHFFRKA
TLKNSERFGT EELARIEGEM LEAREKSANL EYEIFMRIRE EVGKYIQRLQ ALAQGIATVD
VLQGLAVVAE NQHLIRPEFG QESRIDIQNG RHAVVEKVMG AQTYIPNSIQ MDEDTSIQLI
TGPNMSGKST YMRQLAITAV MAQMGSYVPA ESAQLPIFDA IFTRIGAADD LVSGQSTFMV
EMMEANNAIS HATKDSLILF DELGRGTATY DGMALAQSII EYIHEHIGAK TLFATHYHEL
TSLEASLEHL VNVHVATLEQ NGQVTFLHKI EPGPADKSYG IHVAKIAGLP ADLLKRADAI
LTQLESQGQE NPISINQRNV VNEQMSLFDE KEENPILAEL AQVDVYNMTP MQAMNLLLEL
KQKL
//
