ID E8K3R2_STRPA Unreviewed; 600 AA.
AC E8K3R2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Oligoendopeptidase F {ECO:0000313|EMBL:EFX39488.1};
DE EC=3.4.24.- {ECO:0000313|EMBL:EFX39488.1};
GN Name=pepF {ECO:0000313|EMBL:EFX39488.1};
GN ORFNames=HMPREF8577_0197 {ECO:0000313|EMBL:EFX39488.1};
OS Streptococcus parasanguinis ATCC 903.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888048 {ECO:0000313|EMBL:EFX39488.1, ECO:0000313|Proteomes:UP000005490};
RN [1] {ECO:0000313|EMBL:EFX39488.1, ECO:0000313|Proteomes:UP000005490}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 903 {ECO:0000313|EMBL:EFX39488.1,
RC ECO:0000313|Proteomes:UP000005490};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX39488.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEVE01000011; EFX39488.1; -; Genomic_DNA.
DR RefSeq; WP_003006387.1; NZ_GL732449.1.
DR AlphaFoldDB; E8K3R2; -.
DR MEROPS; M03.007; -.
DR eggNOG; COG1164; Bacteria.
DR HOGENOM; CLU_021290_2_0_9; -.
DR Proteomes; UP000005490; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09608; M3B_PepF; 1.
DR Gene3D; 1.10.1370.20; Oligoendopeptidase f, C-terminal domain; 1.
DR Gene3D; 1.20.140.70; Oligopeptidase f, N-terminal domain; 1.
DR Gene3D; 1.10.287.830; putative peptidase helix hairpin domain like; 1.
DR InterPro; IPR013647; OligopepF_N_dom.
DR InterPro; IPR042088; OligoPept_F_C.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR InterPro; IPR004438; Peptidase_M3B.
DR NCBIfam; TIGR00181; pepF; 1.
DR PANTHER; PTHR11804:SF79; MITOCHONDRIAL INTERMEDIATE PEPTIDASE; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR Pfam; PF08439; Peptidase_M3_N; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EFX39488.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 112..181
FT /note="Oligopeptidase F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08439"
FT DOMAIN 202..581
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 600 AA; 69094 MW; 1F2AD8AA9EEEC1EA CRC64;
MVKQRNEIDE KYQWDLSTIF ATDQAWEEEA ASLAADIKAA SHYAGHLLDS AQTLLDTTNA
YLELSRRLEK VYVYAHMKND QDTRVAKYQE YQSKGMSLYS LLGETFAFYE PEFMAITDEQ
YKAFVSEVPA LEQYGHYFDR LLEKKEHVLS QKEEELLAGA GEIFAAGGET FEILDNADIV
FPTVHDDKGE EVQLTHGNYI SLVESKDRAV RKEAYEGLYK VYEQYQHTYA KTLQTNVKVH
NFNAKVRKFS SAREAALSEN FVPESVYDSL VAAVNKHLPL LQRYVQLRSK ILGISDLKMY
DMYTPLSDTD YKFTYEESLA KAEEVLAVLG EDYLSRVKRA FSERWIDVHV NQGKRSGAYS
GGSYDTNAFM LLNWQDTLDN LFTLVHETGH SMHSSYTRET QPYVYGDYSI FLAEIASTTN
ENILTERLLE EVEDDATRFA ILNHFLDGFR GTVFRQTQFA EFEHAIHKAD QEGTVLTSEF
LNNLYAELNE KYYGLSKEDN PEIQYEWARI PHFYYNYYVF QYSTGFAAAS ALAEKIVHGT
QEDRGKYIDY LKAGNSDYPL NVIRKAGVDM EKEDYLDAAF AVFERRLNEF EALVEKLGLA
//
