ID E8KHJ0_9PAST Unreviewed; 1114 AA.
AC E8KHJ0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Transporter, small conductance mechanosensitive ion channel MscS family protein {ECO:0000313|EMBL:EFX91639.1};
GN ORFNames=HMPREF0027_1307 {ECO:0000313|EMBL:EFX91639.1};
OS Actinobacillus ureae ATCC 25976.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=887324 {ECO:0000313|EMBL:EFX91639.1, ECO:0000313|Proteomes:UP000005467};
RN [1] {ECO:0000313|EMBL:EFX91639.1, ECO:0000313|Proteomes:UP000005467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25976 {ECO:0000313|EMBL:EFX91639.1,
RC ECO:0000313|Proteomes:UP000005467};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX91639.1}.
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DR EMBL; AEVG01000094; EFX91639.1; -; Genomic_DNA.
DR RefSeq; WP_005623002.1; NZ_GL831080.1.
DR AlphaFoldDB; E8KHJ0; -.
DR HOGENOM; CLU_007829_2_0_6; -.
DR Proteomes; UP000005467; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF8; MECHANOSENSITIVE CHANNEL MSCK; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1114
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003226627"
FT TRANSMEM 482..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 839..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..901
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 913..941
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..266
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 490..825
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 886..927
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 929..993
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 1003..1085
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT COILED 66..133
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 214..241
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1114 AA; 126111 MW; 9CA97EA3FAFC1189 CRC64;
MIKRLFNPFL FSLTLVLSSH ALWAAELSTE KDIQTQIDET KKLEQNEVNK SLIKSLEDTQ
ALLTQITQQK SDNSALEKEI KGAQAALQVS KTDIAKLQHT PQVTLESLAK YSLDELQNRL
AAAQSSSQTV QQDLTTINGK LVAQNSAPTK AQTVLTTNAT RKQEISTLLG NVNTSQTERA
KLETELALLD LQNAYNQLLL RGSDELAALY NSQLEEKKLV QQNIQNELSQ LQNAINTKLV
EESKNKVEQA AQSQQEGTTS NTNPLIIKQL DLNTRISEEL LKQTTDLTQL SQDNLRIKGV
LDNLQQTQRN IEEQISSLQG TLVLSRIINK QRQSLPQDQM VKGLSKQIAD LRVRVFDLTE
FKDSISDPNV YIAKLEKDEK TELTAKEKDQ LKNILAERSK ILAEMIKSLN NQLNLSINIE
LNQQQVQTIS DTLQKKLEQQ SFWVKSNSPI DLDWFKSFLA VASFQLNDLA KKFDFSNWKD
NIIPASIFEI LLALGVFIIS RRKEQIKQRL TQINNSMKTV ATDSQWNTPL VIFWTLILCL
PSTFIFLMVF ILITYICFQD PTEVWPWGLR MSGYWLYFAF MVAMLRPNGI GYRHFNMPQK
SNAVFRDILK RSVWVIGLML NTAVFSNINE MGIAYDVLGQ VFTIIVLISI IFIVAPGFRQ
AISTYQNVAA DEESPRNLLL NIARTVLFLA PIALVVLIGL GYYYTSLIII EHLVSTYFAV
ITWIILRNVF YRTFNVASRR LAFRRLQEKR EQALAKVTNT EQQIVQSEGD ISFELHDDTL
AVSEIKDQML KLTDLLLWAS LFGLLYWVWS DLVTVAYYLN GVTLWQQETD TATGVVMESI
TLLNLLVAFG ILFVTYVLIR NLSGLLEALV FSNLKLSQGT PYTVTTLLTY LLIVLGATLA
FATLGMSWSK LQWLFTALSV GLGFGMQEIF ANFVSGIIIL FERPVRIGDM ITIGTFNGTV
SKIRIRATTL IDNDSKEVIV PNKAFITERI VNWALTTSMT RLVISVGVAY GSDLDLVKRL
LLQAAEENPS VLKDPAPVAY FLAFGASTLD HELRVHVGQI SDRMRTVDEL NRRINQLFAE
HNIEIAFNQL DIFIKDQATN EEVKWATEKF NDKN
//