ID E8N2P6_ANATU Unreviewed; 368 AA.
AC E8N2P6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE AltName: Full=Galactowaldenase {ECO:0000256|ARBA:ARBA00033067};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN OrderedLocusNames=ANT_08180 {ECO:0000313|EMBL:BAJ62852.1};
OS Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 /
OS UNI-1).
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Anaerolinea.
OX NCBI_TaxID=926569 {ECO:0000313|EMBL:BAJ62852.1, ECO:0000313|Proteomes:UP000008922};
RN [1] {ECO:0000313|EMBL:BAJ62852.1, ECO:0000313|Proteomes:UP000008922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1
RC {ECO:0000313|Proteomes:UP000008922};
RA Narita-Yamada S., Kishi E., Watanabe Y., Takasaki K., Ankai A., Oguchi A.,
RA Fukui S., Takahashi M., Yashiro I., Hosoyama A., Sekiguchi Y., Hanada S.,
RA Fujita N.;
RT "Whole genome sequence of Anaerolinea thermophila UNI-1.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
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DR EMBL; AP012029; BAJ62852.1; -; Genomic_DNA.
DR AlphaFoldDB; E8N2P6; -.
DR STRING; 926569.ANT_08180; -.
DR KEGG; atm:ANT_08180; -.
DR eggNOG; COG0451; Bacteria.
DR HOGENOM; CLU_065334_0_0_0; -.
DR InParanoid; E8N2P6; -.
DR OrthoDB; 9776016at2; -.
DR Proteomes; UP000008922; Chromosome.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Reference proteome {ECO:0000313|Proteomes:UP000008922}.
FT DOMAIN 128..257
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 368 AA; 42613 MW; 835F27DD3ECFAA16 CRC64;
MFRFVRKMVE FSRHCLKKYA RMDISYSQWL KSFGKFFYWR DTMKVCVVGG SGNISTSIVR
LLVSLGHEVY CFNRGKSRPV PEGAKTLTGD RNDRETFEKM MQSYHFDAAI DMMCFTREDA
ESSVRAFRGV SHFVQCSTVC TYGIDYDWLP VTEDHPLRPI TPYGRGKVEA DHVFLEAYHR
EGFPVTIIKP STTYGPIMGL PRQIAWDFSW IDRTRKGKPI VVCGDGNALH QFLHVDDAAP
AFVYVLGRER CLGQVYNMVA RGFTTWAEFH RTAAKVFGKE IELVGIPFAD LKRMNVPEFG
ICEEIFAHHV IYSAEKLFRD VPEFQPRIRL EEGMAQVFEA MEREGRIPNS DALKWEDDII
ARWKKIYQ
//
