ID E8R5Q2_ISOPI Unreviewed; 844 AA.
AC E8R5Q2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Aminopeptidase {ECO:0000313|EMBL:ADV62809.1};
GN OrderedLocusNames=Isop_2231 {ECO:0000313|EMBL:ADV62809.1};
OS Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B).
OC Bacteria; Planctomycetota; Planctomycetia; Isosphaerales; Isosphaeraceae;
OC Isosphaera.
OX NCBI_TaxID=575540 {ECO:0000313|EMBL:ADV62809.1, ECO:0000313|Proteomes:UP000008631};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43644;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders E., Brettin T.,
RA Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Eisen J.A.;
RT "The complete sequence of chromosome of Isophaera pallida ATCC 43644.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV62809.1, ECO:0000313|Proteomes:UP000008631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43644 / DSM 9630 / IS1B
RC {ECO:0000313|Proteomes:UP000008631};
RX PubMed=21475588; DOI=10.4056/sigs.1533840;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Goker M., Cleland D., Saunders E., Lapidus A., Nolan M., Lucas S.,
RA Hammon N., Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Detter J.C., Beck B., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Isosphaera pallida type strain (IS1B).";
RL Stand. Genomic Sci. 4:63-71(2011).
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DR EMBL; CP002353; ADV62809.1; -; Genomic_DNA.
DR RefSeq; WP_013565097.1; NC_014962.1.
DR AlphaFoldDB; E8R5Q2; -.
DR STRING; 575540.Isop_2231; -.
DR KEGG; ipa:Isop_2231; -.
DR eggNOG; COG0308; Bacteria.
DR HOGENOM; CLU_015077_0_0_0; -.
DR InParanoid; E8R5Q2; -.
DR Proteomes; UP000008631; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09604; M1_APN_like; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533:SF303; AMINOPEPTIDASE N; 1.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Aminopeptidase {ECO:0000313|EMBL:ADV62809.1};
KW Hydrolase {ECO:0000313|EMBL:ADV62809.1};
KW Protease {ECO:0000313|EMBL:ADV62809.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008631};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..844
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003230064"
FT DOMAIN 391..587
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT REGION 795..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 94997 MW; EED92F1E64A0289B CRC64;
MILGASRFAS TWLATAGLVA VALTVAPAMS QAQLPPRSPD KFNQDDKFRQ LEEILPTPND
YRTASGAPGA RYWQQRADYS IDVTLDEATN RVNGAETITY YNQSPDTLNY LWLQLDANLF
RPDSDSNLTS TRHFTPAGGE ITPDLVKRVV AREQFDGGVT IEAVTDAQGR PLAHTIVKTM
MRVDLPQPLK PGEQFVFGIK WHYEVNDARL VGGRTGYETF KDGNKVYVIA QWFPRLAAYT
DATGWQHKQY LGSGEFTLEL GDYDVRITVP EDHILAATGV LQNPEEVLTE TQRQRLEQAK
SSTTPVDVVT AEEAKANESK TDKPLGTKTW RFRAENVRDF AFATSRKFLW DAMGVPVGEG
DDRRVVLAMS FYPNEGQPLW GTYSTHAIAH TINVYSRFTF DYPYPVAISV MGPVGGMEYP
MICFNGPRPQ EDGSYSSRTK YALISVVIHE VGHNYFPMIV NSDERQWTWM DEGINTFLQY
LAEQEWEDNY PSSRGEPTAI VEYMKSRDQV PVMTNSESVL QFGNNAYAKP ATALNILRET
ILGRDLFDFA FREYARRWKF KRPMPADFFR TMEDASGVDL DWFWRGWFYS TDHCDLALEK
VTVGILELAP PDSSAPSEPP PVVTLAQERN RNLPKRIDAF PELNDQSNET PKPTEVDLDK
LKRDYETFVE SLPPEDRHLF STPHCFTTVE IRNVGGLVMP VILELQFADG TSDIVRIPAE
IWRYDAEKVT KTLHTTKEVV GVVLDPRLET ADVDTSNNVW PPKEAKSRFQ LFKSGRNGNA
QVNGDAAERL EQLRGRFGSR GRPAAANNAE SNGRTRDAGG ETNTEANRRP NPDPVPAPHR
PGSD
//
