ID E8R986_DESM0 Unreviewed; 643 AA.
AC E8R986;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Alpha-amylase {ECO:0000313|EMBL:ADV65062.1};
DE EC=3.2.1.1 {ECO:0000313|EMBL:ADV65062.1};
GN OrderedLocusNames=Desmu_0757 {ECO:0000313|EMBL:ADV65062.1};
OS Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1).
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Desulfurococcus.
OX NCBI_TaxID=765177 {ECO:0000313|EMBL:ADV65062.1, ECO:0000313|Proteomes:UP000001068};
RN [1] {ECO:0000313|Proteomes:UP000001068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35584 / DSM 2162 / JCM 9187 / O7/1
RC {ECO:0000313|Proteomes:UP000001068};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G.,
RA Chertkov O., Held B., Brettin T., Detter J.C., Tapia R., Han C., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Wirth R., Bilek Y., Hader T., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Desulfurococcus mucosus DSM 2162.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV65062.1, ECO:0000313|Proteomes:UP000001068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35584 / DSM 2162 / JCM 9187 / O7/1
RC {ECO:0000313|Proteomes:UP000001068};
RX PubMed=21677854; DOI=10.4056/sigs.1644004;
RA Wirth R., Chertkov O., Held B., Lapidus A., Nolan M., Lucas S., Hammon N.,
RA Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA Liolios K., Ioanna P., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Bilek Y., Hader T., Rohde M., Spring S., Sikorski J., Goker M., Woyke T.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P.;
RT "Complete genome sequence of Desulfurococcus mucosus type strain (O7/1).";
RL Stand. Genomic Sci. 4:173-182(2011).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 57 family.
CC {ECO:0000256|ARBA:ARBA00006821}.
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DR EMBL; CP002363; ADV65062.1; -; Genomic_DNA.
DR RefSeq; WP_013562284.1; NC_014961.1.
DR AlphaFoldDB; E8R986; -.
DR STRING; 765177.Desmu_0757; -.
DR GeneID; 10153452; -.
DR KEGG; dmu:Desmu_0757; -.
DR eggNOG; arCOG03280; Archaea.
DR HOGENOM; CLU_026700_0_0_2; -.
DR OrthoDB; 18576at2157; -.
DR Proteomes; UP000001068; Chromosome.
DR GO; GO:0004556; F:alpha-amylase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd10793; GH57N_TLGT_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 3.20.110.20; -; 1.
DR InterPro; IPR015179; A-amylase/a-glucTrfase_C.
DR InterPro; IPR015178; A-amylase/a-glucTrfase_central.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR004300; Glyco_hydro_57_N.
DR PANTHER; PTHR36306:SF1; 4-ALPHA-GLUCANOTRANSFERASE; 1.
DR PANTHER; PTHR36306; ALPHA-AMYLASE-RELATED-RELATED; 1.
DR Pfam; PF09094; AmyA-A_glucT_m; 1.
DR Pfam; PF09095; AmyA-gluTrfs_C; 2.
DR Pfam; PF03065; Glyco_hydro_57; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000313|EMBL:ADV65062.1};
KW Hydrolase {ECO:0000313|EMBL:ADV65062.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001068}.
FT DOMAIN 18..266
FT /note="Glycoside hydrolase family 57 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03065"
FT DOMAIN 281..356
FT /note="Alpha-amylase/4-alpha-glucanotransferase central"
FT /evidence="ECO:0000259|Pfam:PF09094"
FT DOMAIN 376..432
FT /note="Alpha-amylase/4-alpha-glucanotransferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09095"
FT DOMAIN 436..623
FT /note="Alpha-amylase/4-alpha-glucanotransferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09095"
SQ SEQUENCE 643 AA; 74485 MW; F62A49A75D64A831 CRC64;
MPRVNFIFAL HFHQPLGQLK GVNEKIFVNS YRLLLDVFKS FADLKFTVHV SGPLLLYLAK
NHPEWLEELF KLGDLGVLEF MAGSLGEAIL PIIPREDREA QIREYIALFE RLSGFKPKGL
WLPERVWEPG LPEVLGKLGV EYVFIDDSTL TKTGHPQDLA YYAWNTEDSG QLVRVFFIDA
GIRYILPWEP PERVLEYLVS KGREGDQARL VLWGSDAEKF GEWMDPERSR SWLYSFLELM
RRSRDRVSMT HPSEYLMEHG VRGLLYFDTG SYDKMLEWSR GFFRNFLVKY RESNNMHKKM
LWVRRKLGSL DSVPEEVRTG YLLSQCNDAY WHGLFGGIYL AHLRQAIYEE LIRTEAWAER
ETGYFRDTGV RVGMVDFDYD GEPEVLVETP SQNLYVKPDD GGTLFEYDVK SRGLEHNLQD
TMSRYGEPYI NKPGFHPDWY RRVSWRIHLW SDDTGLYDWI NNTPFKDMSD LALKKHHVAV
GEGNEITLRA LGGFYQYGST PVTVMVEKKI NLTDKGHAVT YRIRNMGDKT FSTRLGIEYH
VAWKIDREND EKPYYVVEGV SRDVSESGVF HTERITVGSA GYPSIVLEAS KPHEAWIAQL
ASLSRTEKGF KEMPQGLGVM FTRQLVLKPG EEYEASVSWM LKA
//
