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Database: UniProt
Entry: E8RCM9_DESPD
LinkDB: E8RCM9_DESPD
Original site: E8RCM9_DESPD 
ID   E8RCM9_DESPD            Unreviewed;       439 AA.
AC   E8RCM9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-JUL-2017, entry version 47.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Despr_0641 {ECO:0000313|EMBL:ADW16817.1};
OS   Desulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales;
OC   Desulfobulbaceae; Desulfobulbus.
OX   NCBI_TaxID=577650 {ECO:0000313|EMBL:ADW16817.1, ECO:0000313|Proteomes:UP000006365};
RN   [1] {ECO:0000313|EMBL:ADW16817.1, ECO:0000313|Proteomes:UP000006365}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33891 / DSM 2032 / 1pr3
RC   {ECO:0000313|Proteomes:UP000006365};
RX   PubMed=21475592;
RA   Pagani I., Lapidus A., Nolan M., Lucas S., Hammon N., Deshpande S.,
RA   Cheng J.F., Chertkov O., Davenport K., Tapia R., Han C., Goodwin L.,
RA   Pitluck S., Liolios K., Mavromatis K., Ivanova N., Mikhailova N.,
RA   Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Detter J.C., Brambilla E., Kannan K.P., Djao O.D.,
RA   Rohde M., Pukall R., Spring S., Goker M., Sikorski J., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Desulfobulbus propionicus type strain
RT   (1pr3).";
RL   Stand. Genomic Sci. 4:100-110(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002364; ADW16817.1; -; Genomic_DNA.
DR   RefSeq; WP_015723362.1; NC_014972.1.
DR   STRING; 577650.Despr_0641; -.
DR   EnsemblBacteria; ADW16817; ADW16817; Despr_0641.
DR   KEGG; dpr:Despr_0641; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; VENWVKD; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006365; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006365};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006365}.
FT   DOMAIN      348    416       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     145    152       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   439 AA;  48738 MW;  EF28B4860C4A46AA CRC64;
     MLWNAIKTSL HGAIPESEFG LWIKPLECRR HDDGVLELVG PDRFFCAWVE DRYLGLIRTK
     AAELGEITDV RLQAAATPPL RFESGKGGQL KLPGVTSAGP RLRSLHPAFT FEQFMVGESN
     LLARSACQAL ATGDATFGNC LFMNSTTGLG KSHLTQAVVH QVLRSAPSTR LHYLTAQQFS
     AEMVKGIRTN AMEQFSKKYI NDCDMLLVED VHTLTGKTKT QEELNTILDY LIKSGRRVIL
     TSALPPTKLA GIDDDFRSRM TSGLVTGIES PDYETRARII RHKLQMHGLG ADEDLVGFMA
     ESLQGDVRRM ESAIIGIKAK SCLLGAPPDL GMVREVVYGL IGSRADITGE AIRELIGRQF
     RVSIEDLCSR SRKRSITFPR QLAMYLTRKY TTKSLADIGS LYNRDHSTVL YAIKTITKDM
     SQQTTVRQQV ELLSAKLKN
//
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