ID E8RTY9_ASTEC Unreviewed; 514 AA.
AC E8RTY9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ADU14960.1};
GN OrderedLocusNames=Astex_3326 {ECO:0000313|EMBL:ADU14960.1};
OS Asticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / KCTC 12464 /
OS NCIMB 9791 / VKM B-1370 / CB 48).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Asticcacaulis.
OX NCBI_TaxID=573065 {ECO:0000313|EMBL:ADU14960.1, ECO:0000313|Proteomes:UP000001492};
RN [1] {ECO:0000313|Proteomes:UP000001492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15261 / DSM 4724 / KCTC 12464 / NCIMB 9791 / VKM B-1370 /
RC CB 48 {ECO:0000313|Proteomes:UP000001492};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Teshima H., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G.,
RA Brun Y.V., Woyke T.;
RT "Complete sequence of chromosome 2 of Asticcacaulis excentricus CB 48.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP002396; ADU14960.1; -; Genomic_DNA.
DR RefSeq; WP_013480777.1; NC_014817.1.
DR AlphaFoldDB; E8RTY9; -.
DR STRING; 573065.Astex_3326; -.
DR KEGG; aex:Astex_3326; -.
DR eggNOG; COG0665; Bacteria.
DR HOGENOM; CLU_022247_0_0_5; -.
DR OrthoDB; 7178350at2; -.
DR Proteomes; UP000001492; Chromosome 2.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001492}.
FT ACT_SITE 81
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 12..15
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 81
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 340
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 349
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 353
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 514 AA; 58114 MW; AB0CDF97B456162D CRC64;
MTGKRRLLIL GGGTAGWLAA AYLARYFDLN RQPRLELVLV ESPEINSVGV GEGTFPTIRQ
TLKFIGIDEA RFMRRTTATF KQGIRFADWV KTPVNGQHSH YFHPFEAPYY TEGEGLVPYW
LLQDEATRKP FAEAVTFQKR VAEARRAPKR PHEGDFAGPL NYAYHFDAYQ LAEVLAERAV
ALGVLHKPAR LDGVVLDHTG QIDHIVADGE VLRADLYIDC SGFRAELIGK ALGSPFRSVR
DTLFTNKALA CKAPYERPDT PIESYTVATG HSAGWTWDIG LVGQRGIGYT YSTDHTSDDE
AEATLHRYVG SKAPLNLREI AFEPGYRERP WIGNCVAVGL AGGFMEPLES TGIVMIEVAV
AMIAELFPHA GPIDAPARRF NALMTARYEH IVNFLKLHYA LSRRSEAFWR DNADPQTWPD
RLRELLDQWR YRPPSRFDFL IDVETFAFFN YQYILYGMGY RTDLSGARDQ FPHVEDANRT
FAKIHNFGER ATLDLPPHRT LIRQIYAEGF AESA
//
