ID E8T2A3_THEA1 Unreviewed; 476 AA.
AC E8T2A3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=DNA mismatch repair protein domain protein {ECO:0000313|EMBL:ADU96998.1};
GN OrderedLocusNames=Theam_1031 {ECO:0000313|EMBL:ADU96998.1};
OS Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1).
OC Bacteria; Aquificota; Aquificae; Desulfurobacteriales;
OC Desulfurobacteriaceae; Thermovibrio.
OX NCBI_TaxID=648996 {ECO:0000313|EMBL:ADU96998.1, ECO:0000313|Proteomes:UP000006362};
RN [1] {ECO:0000313|EMBL:ADU96998.1, ECO:0000313|Proteomes:UP000006362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15698 / JCM 12110 / HB-1
RC {ECO:0000313|Proteomes:UP000006362};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Ovchinnikova G., Vetriani C., Woyke T.;
RT "Complete sequence of chromosome of Thermovibrio ammonificans HB-1.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CP002444; ADU96998.1; -; Genomic_DNA.
DR RefSeq; WP_013537784.1; NC_014926.1.
DR AlphaFoldDB; E8T2A3; -.
DR STRING; 648996.Theam_1031; -.
DR KEGG; tam:Theam_1031; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_0; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000006362; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 2.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204}.
FT DOMAIN 197..291
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
SQ SEQUENCE 476 AA; 54183 MW; 7B57113D97D0F954 CRC64;
MIKRLPREVV ARIASGQIAS SPAAVLKELI ENALDAKASE VKVQVETPFN FRVSDNGIGI
PYRELPLAVE RFTTSKIFSV EELERVTSYG FRGEALFAIS QFSTLEIKSR HEAEEVGGKL
VVTAGEVKEY SPIPFRRGTT VTVSNLFFNV PVRRKATSQK ERSLMERLTL RYALANPHVT
FKFGELTLPA TSLKERLIQV TRGKPKFQLI EGDGVTLFFS REERGPRELF VNRRPVSVPE
VERLLEEFGV KAFVLFMELP PEEVDFNVSP LKEKVLFKSE RGVKALRELL EGEFNLPKPS
VQRAKAEEDT GPIELIGSDG TVLIAHDRKF YYFFDQHLIH ERVNYEELLK ALFAGKVKKV
KLVPPVTVPV TVKEKLDAIH AVYAESEKGL TVYEAPELIT PEEIKKLESQ PLETVASVAC
RRAVKAGYVF KEFKELESLF NRYLRCAEKE RCPHGRPIYY KVRKQVIYSH LGRKRI
//
