ID E8TNV0_MESCW Unreviewed; 350 AA.
AC E8TNV0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein {ECO:0000313|EMBL:ADV15379.1};
GN OrderedLocusNames=Mesci_6404 {ECO:0000313|EMBL:ADV15379.1};
OS Mesorhizobium ciceri biovar biserrulae (strain HAMBI 2942 / LMG 23838 /
OS WSM1271).
OG Plasmid pMESCI01 {ECO:0000313|EMBL:ADV15379.1,
OG ECO:0000313|Proteomes:UP000007471}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Phyllobacteriaceae; Mesorhizobium.
OX NCBI_TaxID=765698 {ECO:0000313|EMBL:ADV15379.1, ECO:0000313|Proteomes:UP000007471};
RN [1] {ECO:0000313|Proteomes:UP000007471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HAMBI 2942 / LMG 23838 / WSM1271
RC {ECO:0000313|Proteomes:UP000007471};
RC PLASMID=Plasmid pMESCI01 {ECO:0000313|Proteomes:UP000007471};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Nandasena K., Reeve W.G., Howieson J.G., O'Hara G.,
RA Tiwari R.P., Woyke T.;
RT "Complete sequence of plasmid of Mesorhizobium ciceri bv. biserrulae
RT WSM1271.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002448; ADV15379.1; -; Genomic_DNA.
DR RefSeq; YP_004134553.1; NC_014918.1.
DR AlphaFoldDB; E8TNV0; -.
DR KEGG; mci:Mesci_6404; -.
DR PATRIC; fig|765698.3.peg.339; -.
DR eggNOG; COG1052; Bacteria.
DR HOGENOM; CLU_019796_1_3_5; -.
DR OMA; NARATIM; -.
DR OrthoDB; 9793626at2; -.
DR Proteomes; UP000007471; Plasmid pMESCI01.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Plasmid {ECO:0000313|EMBL:ADV15379.1}.
FT DOMAIN 50..118
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 119..294
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 350 AA; 37965 MW; 0E8EE48B79F4C477 CRC64;
MGDLKFKVAL SGDFRMPDGS LTYPDFDLEP LRKAPGLEMT FLESNNPLRA DQLEDFDALI
LLTHRFVSTS VPKSGRLAVV ARFGVGYDTV DVEACTAAGI ALVITPDGVR RPVAVSVITF
MLALTGKLFT KDALTRKGPH GFQERSQHMG VGLVGRTLGS LGIGNIGAEV FRLAKPFDMR
FIAHDPFADK KVAAELGVEL VGLEDLFRRA DVLSVSCPLT PDTRHLVSAE RLALMKPTAY
LINTARGPIV DQKALAQALR ERRIAGAGLD VLEQEPPDAD DAILKLDNVI LAPHALCWTD
QCFAGNGAAD VKAVIEVQHG REPRGVVNRE VLSSERWKDR LAVFAGRFGS
//