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Database: UniProt
Entry: E8TNV0_MESCW
LinkDB: E8TNV0_MESCW
Original site: E8TNV0_MESCW 
ID   E8TNV0_MESCW            Unreviewed;       350 AA.
AC   E8TNV0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 57.
DE   SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein {ECO:0000313|EMBL:ADV15379.1};
GN   OrderedLocusNames=Mesci_6404 {ECO:0000313|EMBL:ADV15379.1};
OS   Mesorhizobium ciceri biovar biserrulae (strain HAMBI 2942 / LMG 23838 /
OS   WSM1271).
OG   Plasmid pMESCI01 {ECO:0000313|EMBL:ADV15379.1,
OG   ECO:0000313|Proteomes:UP000007471}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=765698 {ECO:0000313|EMBL:ADV15379.1, ECO:0000313|Proteomes:UP000007471};
RN   [1] {ECO:0000313|Proteomes:UP000007471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAMBI 2942 / LMG 23838 / WSM1271
RC   {ECO:0000313|Proteomes:UP000007471};
RC   PLASMID=Plasmid pMESCI01 {ECO:0000313|Proteomes:UP000007471};
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Nandasena K., Reeve W.G., Howieson J.G., O'Hara G.,
RA   Tiwari R.P., Woyke T.;
RT   "Complete sequence of plasmid of Mesorhizobium ciceri bv. biserrulae
RT   WSM1271.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC       ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; CP002448; ADV15379.1; -; Genomic_DNA.
DR   RefSeq; YP_004134553.1; NC_014918.1.
DR   AlphaFoldDB; E8TNV0; -.
DR   KEGG; mci:Mesci_6404; -.
DR   PATRIC; fig|765698.3.peg.339; -.
DR   eggNOG; COG1052; Bacteria.
DR   HOGENOM; CLU_019796_1_3_5; -.
DR   OMA; NARATIM; -.
DR   OrthoDB; 9793626at2; -.
DR   Proteomes; UP000007471; Plasmid pMESCI01.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR   PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW   Plasmid {ECO:0000313|EMBL:ADV15379.1}.
FT   DOMAIN          50..118
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          119..294
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   350 AA;  37965 MW;  0E8EE48B79F4C477 CRC64;
     MGDLKFKVAL SGDFRMPDGS LTYPDFDLEP LRKAPGLEMT FLESNNPLRA DQLEDFDALI
     LLTHRFVSTS VPKSGRLAVV ARFGVGYDTV DVEACTAAGI ALVITPDGVR RPVAVSVITF
     MLALTGKLFT KDALTRKGPH GFQERSQHMG VGLVGRTLGS LGIGNIGAEV FRLAKPFDMR
     FIAHDPFADK KVAAELGVEL VGLEDLFRRA DVLSVSCPLT PDTRHLVSAE RLALMKPTAY
     LINTARGPIV DQKALAQALR ERRIAGAGLD VLEQEPPDAD DAILKLDNVI LAPHALCWTD
     QCFAGNGAAD VKAVIEVQHG REPRGVVNRE VLSSERWKDR LAVFAGRFGS
//
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