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Database: UniProt
Entry: E8UFF2_TAYEM
LinkDB: E8UFF2_TAYEM
Original site: E8UFF2_TAYEM 
ID   E8UFF2_TAYEM            Unreviewed;       520 AA.
AC   E8UFF2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-JUL-2017, entry version 49.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=TEQUI_0628 {ECO:0000313|EMBL:ADU91566.1};
OS   Taylorella equigenitalis (strain MCE9).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Taylorella.
OX   NCBI_TaxID=937774 {ECO:0000313|EMBL:ADU91566.1, ECO:0000313|Proteomes:UP000007472};
RN   [1] {ECO:0000313|EMBL:ADU91566.1, ECO:0000313|Proteomes:UP000007472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MCE9 {ECO:0000313|EMBL:ADU91566.1,
RC   ECO:0000313|Proteomes:UP000007472};
RX   PubMed=21278298; DOI=10.1128/JB.01547-10;
RA   Hebert L., Moumen B., Duquesne F., Breuil M.F., Laugier C.,
RA   Batto J.M., Renault P., Petry S.;
RT   "Genome sequence of Taylorella equigenitalis MCE9, the causative agent
RT   of contagious equine metritis.";
RL   J. Bacteriol. 193:1785-1785(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002456; ADU91566.1; -; Genomic_DNA.
DR   STRING; 937774.TEQUI_0628; -.
DR   EnsemblBacteria; ADU91566; ADU91566; TEQUI_0628.
DR   KEGG; teq:TEQUI_0628; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000007472; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007472};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007472}.
FT   DOMAIN      212    347       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      428    497       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     220    227       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   520 AA;  59955 MW;  6DF2F378DF84255A CRC64;
     MGEFWQECLT KLTEILDENI VHKWIKPLKP LGFSEDDTVI KLEAPTELKK NWVQSYYANT
     IRDVILEILN INVRVEVVLA PKPQTSSETI PSADFNPNDP VVSAEKPIID RSIATPTKES
     YRDKTFEDNT FVMEFEPEKG ESEAVESIEA LPEPMGRYAY RGMAEIPRDM QQFYKATNLN
     QRLTFQNLVV GDSNELAYVT AQNVVRNIGK HGYNPLFIYG KTGLGKTHIM HAIGNELFTK
     HKMRNVLYIH AETYYTEITR RMIEGRWVEY RAQDNKYINS DLLLMDDVQL FARKERTQQE
     FFVLYEALVN NDKQVVISCD TFPDNLDAIE DRLKSRFQNG LIIEIEPPDV ELRVSILKSK
     AKDFPDMEFT DEVALYIASN IKSNVRELEG ALQKVMAYSQ FKQIDKPTVD TCKAALRDVL
     RQRNGSLTVE NIQKTVADYY KIRISDIYSK SRSANLVKAR HVAMYLTKEL TRNSLPEIGQ
     SFGGRDHSTI HHAVEKIASR RREDRQLNHD IRVLEQILGS
//
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