ID E8USJ2_THEBF Unreviewed; 409 AA.
AC E8USJ2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Uracil-xanthine permease {ECO:0000313|EMBL:ADV80813.1};
GN OrderedLocusNames=Thebr_2310 {ECO:0000313|EMBL:ADV80813.1};
OS Thermoanaerobacter brockii subsp. finnii (strain ATCC 43586 / DSM 3389 /
OS AKO-1) (Thermoanaerobacter finnii).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacter.
OX NCBI_TaxID=509193 {ECO:0000313|EMBL:ADV80813.1, ECO:0000313|Proteomes:UP000002062};
RN [1] {ECO:0000313|EMBL:ADV80813.1, ECO:0000313|Proteomes:UP000002062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43586 / DSM 3389 / AKO-1
RC {ECO:0000313|Proteomes:UP000002062};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Hemme C.L., Woyke T.;
RT "Complete sequence of Thermoanaerobacter brockii finnii Ako-1.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; CP002466; ADV80813.1; -; Genomic_DNA.
DR RefSeq; WP_009052081.1; NC_014964.1.
DR AlphaFoldDB; E8USJ2; -.
DR KEGG; tbo:Thebr_2310; -.
DR HOGENOM; CLU_017959_1_2_9; -.
DR Proteomes; UP000002062; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 409 AA; 42713 MW; 85638C56CC86B2DA CRC64;
MKVLTVGTKE LSGPIKEGDK ISLLQLLILG LQHTFTMFGA TVLVPLLTGL DVGVALFTAG
IGTLWFHLVT KRKVPIFLGS SFAFIAPVAL VVKQWGVPAA QGGIIVAGLL YGLMAVLVYF
LGREFMENLL PPVVTGPIIM VIGLNLAPVA IKSASQNWMV ALIVLTTVIL VSMYGRGFFK
LVPVLVGLIV GYGVSLIFGI VDLKPVQEAA LFAVPAFTKP EFNPAAIGLI APVAVATIVE
HVGDVLAVGA TVQKDFVKDP GLHRTLIGDG IATSLAGLFG GPANTTYSEN TGVLALTGVW
KPEVMRVAAV MAMILSTCQK LTALIRTVPE PVIGGISIIL FGMIASIGIR TVVENAVDFK
KSRNLIISSA ILVFGIGGAV VNLWGGIQLG GVGLAAIIGI ILNQVLPKE
//
