ID E8XG79_SALT4 Unreviewed; 446 AA.
AC E8XG79;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Citrate-sodium symporter {ECO:0000256|ARBA:ARBA00016349, ECO:0000256|PIRNR:PIRNR005348};
GN OrderedLocusNames=STM474_0060 {ECO:0000313|EMBL:ADX15805.1};
OS Salmonella typhimurium (strain 4/74).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=909946 {ECO:0000313|EMBL:ADX15805.1, ECO:0000313|Proteomes:UP000008978};
RN [1] {ECO:0000313|EMBL:ADX15805.1, ECO:0000313|Proteomes:UP000008978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4/74 {ECO:0000313|Proteomes:UP000008978};
RX PubMed=21478351; DOI=10.1128/JB.00394-11;
RA Richardson E.J., Limaye B., Inamdar H., Datta A., Manjari K.S.,
RA Pullinger G.D., Thomson N.R., Joshi R.R., Watson M., Stevens M.P.;
RT "Genome sequences of Salmonella enterica serovar typhimurium, Choleraesuis,
RT Dublin, and Gallinarum strains of well- defined virulence in food-producing
RT animals.";
RL J. Bacteriol. 193:3162-3163(2011).
CC -!- FUNCTION: Uptake of citrate across the boundary membrane with the
CC concomitant uptake of a sodium ion (symport system).
CC {ECO:0000256|ARBA:ARBA00002078, ECO:0000256|PIRNR:PIRNR005348}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:citrate (SCF) symporter family.
CC {ECO:0000256|ARBA:ARBA00007546, ECO:0000256|PIRNR:PIRNR005348}.
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DR EMBL; CP002487; ADX15805.1; -; Genomic_DNA.
DR RefSeq; WP_000183602.1; NC_016857.1.
DR AlphaFoldDB; E8XG79; -.
DR SMR; E8XG79; -.
DR KEGG; seb:STM474_0060; -.
DR PATRIC; fig|909946.3.peg.62; -.
DR HOGENOM; CLU_041211_0_1_6; -.
DR Proteomes; UP000008978; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006101; P:citrate metabolic process; IEA:UniProtKB-UniRule.
DR InterPro; IPR018025; 2-OHcarbox_trans_Prot/Firm.
DR InterPro; IPR004679; 2-OHcarboxylate_transport.
DR NCBIfam; TIGR00783; ccs; 1.
DR PANTHER; PTHR40033:SF1; CITRATE-SODIUM SYMPORTER; 1.
DR PANTHER; PTHR40033; NA(+)-MALATE SYMPORTER; 1.
DR Pfam; PF03390; 2HCT; 1.
DR PIRSF; PIRSF005348; YxkH; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR005348};
KW Citrate utilization {ECO:0000256|ARBA:ARBA00022948,
KW ECO:0000256|PIRNR:PIRNR005348};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005348};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|PIRNR:PIRNR005348};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005348}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 446 AA; 47622 MW; 58A22E78AC7F4121 CRC64;
MTNMTQASAT EKKGASDLLR FKIFGMPLPL YAFALITLLL SHFYNAIPTD LVGGFALMFV
MGAIFGEIGK RLPIFNKYIG GAPVMIFLVA AYFVYAGIFT QKEIDAISNV MDKSNFLNLF
IAVLITGAIL SVNRKLLLKS LLGYIPTILA GIVGASLFGI VIGLCFGIPV DRIMMLYVLP
IMGGGNGAGA VPLSEIYHSV TGRSREEYYS TAIAILTIAN IFAIIFAALL DMIGKKYTWL
SGEGELVRKA SFKTEDDEKA GQITHRETAV GMVLSTTCFL LAYVVAKKIL PSIGGVSIHY
FAWMVLIVAA LNASGLCSPE IKAGAKRLSD FFSKQLLWVL MVGVGVCYTD LQEIIDALTF
ANVVIAAIIV VGAVVGAAIG GWLIGFYPIE SSITAGLCMA NRGGSGDLEV LSACNRMNLI
SYAQISSRLG GGIVLVIASI VFSMMV
//
