ID E8XH89_SALT4 Unreviewed; 497 AA.
AC E8XH89;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000256|HAMAP-Rule:MF_02219};
GN Name=ssaC {ECO:0000313|EMBL:ADX17096.1};
GN Synonyms=sctC {ECO:0000256|HAMAP-Rule:MF_02219};
GN OrderedLocusNames=STM474_1400 {ECO:0000313|EMBL:ADX17096.1};
OS Salmonella typhimurium (strain 4/74).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=909946 {ECO:0000313|EMBL:ADX17096.1, ECO:0000313|Proteomes:UP000008978};
RN [1] {ECO:0000313|EMBL:ADX17096.1, ECO:0000313|Proteomes:UP000008978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4/74 {ECO:0000313|Proteomes:UP000008978};
RX PubMed=21478351; DOI=10.1128/JB.00394-11;
RA Richardson E.J., Limaye B., Inamdar H., Datta A., Manjari K.S.,
RA Pullinger G.D., Thomson N.R., Joshi R.R., Watson M., Stevens M.P.;
RT "Genome sequences of Salmonella enterica serovar typhimurium, Choleraesuis,
RT Dublin, and Gallinarum strains of well- defined virulence in food-producing
RT animals.";
RL J. Bacteriol. 193:3162-3163(2011).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|HAMAP-Rule:MF_02219,
CC ECO:0000256|RuleBase:RU004004}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000256|ARBA:ARBA00007032, ECO:0000256|HAMAP-
CC Rule:MF_02219}.
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DR EMBL; CP002487; ADX17096.1; -; Genomic_DNA.
DR RefSeq; WP_000261284.1; NC_016857.1.
DR AlphaFoldDB; E8XH89; -.
DR SMR; E8XH89; -.
DR KEGG; seb:STM474_1400; -.
DR PATRIC; fig|909946.3.peg.1435; -.
DR HOGENOM; CLU_022474_4_0_6; -.
DR Proteomes; UP000008978; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR Gene3D; 3.55.50.30; -; 1.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR NCBIfam; TIGR02516; type_III_yscC; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF4; TYPE 3 SECRETION SYSTEM SECRETIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR PRINTS; PR01337; TYPE3OMGPROT.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02219};
KW Protein transport {ECO:0000256|HAMAP-Rule:MF_02219};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_02219};
KW Translocation {ECO:0000256|ARBA:ARBA00023010, ECO:0000256|HAMAP-
KW Rule:MF_02219};
KW Transport {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|RuleBase:RU004004}.
FT DOMAIN 178..267
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 331..490
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
SQ SEQUENCE 497 AA; 54113 MW; B9E7E0B754A5DB31 CRC64;
MVVNKRLILI LLFILNTAKS DELSWKGNDF TLYARQMPLA EVLHLLSENY DTAITISPLI
TATFSGKIPP GPPVDILNNL AAQYDLLTWF DGSMLYVYPA SLLKHQVITF NILSTGRFIH
YLRSQNILSS PGCEVKEITG TKAVEVSGVP SCLTRISQLA SVLDNALIKR KDSAVSVSIY
TLKYATAMDT QYQYRDQSVV VPGVVSVLRE MSKTSVPTSS TNNGSPATQA LPMFAADPRQ
NAVIVRDYAA NMAGYRKLIT ELDQRQQMIE ISVKIIDVNA GDINQLGIDW GTAVSLGGKK
IAFNTGLNDG GASGFSTVIS DTSNFMVRLN ALEKSSQAYV LSQPSVVTLN NIQAVLDKNI
TFYTKLQGEK VAKLESITTG SLLRVTPRLL NDNGTQKIML NLNIQDGQQS DTQSETDPLP
EVQNSEIASQ ATLLAGQSLL LGGFKQGKQI HSQNKIPLLG DIPVVGHLFR NDTTQVHSVI
RLFLIKASVV NNGISHG
//
