ID   E8XHW7_SALT4            Unreviewed;       796 AA.
AC   E8XHW7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Glucose dehydrogenase {ECO:0000313|EMBL:ADX15919.1};
GN   Name=gcd {ECO:0000313|EMBL:ADX15919.1};
GN   OrderedLocusNames=STM474_0178 {ECO:0000313|EMBL:ADX15919.1};
OS   Salmonella typhimurium (strain 4/74).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=909946 {ECO:0000313|EMBL:ADX15919.1, ECO:0000313|Proteomes:UP000008978};
RN   [1] {ECO:0000313|EMBL:ADX15919.1, ECO:0000313|Proteomes:UP000008978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4/74 {ECO:0000313|Proteomes:UP000008978};
RX   PubMed=21478351; DOI=10.1128/JB.00394-11;
RA   Richardson E.J., Limaye B., Inamdar H., Datta A., Manjari K.S.,
RA   Pullinger G.D., Thomson N.R., Joshi R.R., Watson M., Stevens M.P.;
RT   "Genome sequences of Salmonella enterica serovar typhimurium, Choleraesuis,
RT   Dublin, and Gallinarum strains of well- defined virulence in food-producing
RT   animals.";
RL   J. Bacteriol. 193:3162-3163(2011).
CC   -!- COFACTOR:
CC       Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI:58442;
CC         Evidence={ECO:0000256|ARBA:ARBA00001931};
CC   -!- SIMILARITY: Belongs to the bacterial PQQ dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00008156}.
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DR   EMBL; CP002487; ADX15919.1; -; Genomic_DNA.
DR   RefSeq; WP_000829731.1; NC_016857.1.
DR   AlphaFoldDB; E8XHW7; -.
DR   KEGG; seb:STM474_0178; -.
DR   PATRIC; fig|909946.3.peg.186; -.
DR   HOGENOM; CLU_018478_1_0_6; -.
DR   Proteomes; UP000008978; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   CDD; cd10280; PQQ_mGDH; 1.
DR   Gene3D; 2.140.10.10; Quinoprotein alcohol dehydrogenase-like superfamily; 1.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR017511; PQQ_mDH.
DR   InterPro; IPR002372; PQQ_repeat.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR001479; Quinoprotein_DH_CS.
DR   NCBIfam; TIGR03074; PQQ_membr_DH; 1.
DR   PANTHER; PTHR32303; QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C); 1.
DR   PANTHER; PTHR32303:SF4; QUINOPROTEIN GLUCOSE DEHYDROGENASE; 1.
DR   Pfam; PF01011; PQQ; 5.
DR   SMART; SM00564; PQQ; 6.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS00364; BACTERIAL_PQQ_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   PQQ {ECO:0000256|ARBA:ARBA00022891};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        41..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        65..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        121..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   796 AA;  86495 MW;  0E90312EF2251E27 CRC64;
     MAENNARSPR LLVTLTALFA ALCGLYLLIG GVWLVAIGGS WYYPIAGLVM LVVAGLLWRS
     KRAALWLYAA LLLATMIWGV WEVGFDFWAL TPRSDILVFF GIWLILPFVW HRLVVPSSGA
     VAALVVALLI SGGILTWAGF NDPQEINGTL RADATPAATS SSIADEDWPA YGRNQEGQRY
     SPLKQITADN VHQLKEAWVF RTGDLKQPND PGEITNEVTP IKVGDTLYLC TAHQRLFALD
     AASGKEKWHF DPQLKTDSSF QHVTCRGVSY HEAKADTASP EVIADCPRRI ILPVNDGRLF
     AVNAETGKLC ETFANKGVLN LQTNMPDTTP GLYEPTSPPI ITDKTIVIAG SVTDNFSTRE
     TSGVIRGFDV NSGKLMWAFD PGAKDPNAIP ADEHAFTFNS PNSWAPAAYD AKLDLVYLPM
     GVTTPDIWGG NRTPEQERYA SSILALNATT GKLAWSYQTV HHDLWDMDLP AQPTLADITV
     DGTTVPVIYA PAKTGNIFVL DRRNGELVVP APEKPVPQGA AKGDYVAKTQ PFSDLTFRPK
     KDLSGADMWG ATMFDQLVCR VMFHQLRYEG IFTPPSEQGT LVFPGNLGMF EWGGISVDPD
     RQVAIANPMA LPFVSKLIPR GPGNPMEPPK DAKGTGTEAG IQPQYGVPFG VTLNPFLSPF
     GLPCKQPAWG YISALDLKTN EIVWKKRIGT PRDSMPFPMP VPVPFNMGMP MLGGPISTAG
     NVLFIAATAD NYLRAYNMSN GEKLWQGRLP AGGQATPMTY EVNGKQYVVV SAGGHGSFGT
     KMGDYIVAYA LPDDAK
//