ID E8Z387_9INFA Unreviewed; 160 AA.
AC E8Z387;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE Flags: Fragment;
GN Name=PB1 {ECO:0000313|EMBL:ADW65840.1};
OS Influenza A virus (A/Thailand/CU-H1774/2010(H1N1)).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC Alphainfluenzavirus influenzae; Influenza A virus.
OX NCBI_TaxID=980099 {ECO:0000313|EMBL:ADW65840.1};
RN [1] {ECO:0000313|EMBL:ADW65840.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/Thailand/CU-H1774/2010 {ECO:0000313|EMBL:ADW65840.1};
RA Prachayangprecha S., Makkoch J., Posuwan N., Poomipak W., Payungporn S.,
RA Theamboonlers A., Poovorawan Y.;
RT "Hot Spot Molecular Surveillance of Pandemic H1N1 in Thailand.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC replication and transcription of virus RNA segments. The transcription
CC of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC transcription of viral mRNAs. During virus replication, PB1 initiates
CC RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC serves as a template for the production of more vRNAs.
CC {ECO:0000256|ARBA:ARBA00002148}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CY081167; ADW65840.1; -; Viral_cRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR InterPro; IPR001407; RNA_pol_PB1_influenza.
DR Pfam; PF00602; Flu_PB1; 1.
PE 4: Predicted;
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023103};
KW Eukaryotic host transcription shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022731};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00023103};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host RNA polymerase II by virus
KW {ECO:0000256|ARBA:ARBA00023103};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADW65840.1"
FT NON_TER 160
FT /evidence="ECO:0000313|EMBL:ADW65840.1"
SQ SEQUENCE 160 AA; 17645 MW; 4DDD9D9BB9EEEA25 CRC64;
TLLFLKIPAQ NAISTTFPYT GDPPYSHGTG TGYTMDTVNR THQYSEKGKW TTNTETGAPQ
LNPIDGPLPE DNEPSGYAQT DCVLEAMAFL EESHPGIFEN SCLETMEVVQ QTRVDKLTQG
RQTYDWTLNR NQPAATALAN TIEVFRSNGL TANESGRLID
//
