ID E9AC00_LEIMA Unreviewed; 195 AA.
AC E9AC00;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Glutaredoxin-like protein {ECO:0000313|EMBL:CBZ11814.1};
GN ORFNames=LMJF_01_0110 {ECO:0000313|EMBL:CBZ11814.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ11814.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=10077609; DOI=10.1073/pnas.96.6.2902;
RA Myler P.J., Audleman L., deVos T., Hixson G., Kiser P., Lemley C.,
RA Magness C., Rickel E., Sisk E., Sunkin S., Swartzell S., Westlake T.,
RA Bastien P., Fu G., Ivens A., Stuart K.;
RT "Leishmania major Friedlin chromosome 1 has an unusual distribution of
RT protein-coding genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:2902-2906(1999).
RN [2] {ECO:0000313|EMBL:CBZ11814.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [3] {ECO:0000313|EMBL:CBZ11814.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796397; CBZ11814.1; -; Genomic_DNA.
DR RefSeq; XP_003721531.1; XM_003721483.1.
DR AlphaFoldDB; E9AC00; -.
DR STRING; 5664.E9AC00; -.
DR EnsemblProtists; CBZ11814; CBZ11814; LMJF_01_0110.
DR GeneID; 12983104; -.
DR KEGG; lma:LMJF_01_0110; -.
DR VEuPathDB; TriTrypDB:LmjF.01.0110; -.
DR VEuPathDB; TriTrypDB:LMJFC_010006100; -.
DR VEuPathDB; TriTrypDB:LMJLV39_010006000; -.
DR VEuPathDB; TriTrypDB:LMJSD75_010006100; -.
DR eggNOG; KOG0911; Eukaryota.
DR HOGENOM; CLU_026126_3_1_1; -.
DR InParanoid; E9AC00; -.
DR OMA; CAFSKRM; -.
DR Proteomes; UP000000542; Chromosome 1.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISO:GeneDB.
DR GO; GO:0004362; F:glutathione-disulfide reductase (NADP) activity; ISO:GeneDB.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045454; P:cell redox homeostasis; ISO:GeneDB.
DR CDD; cd03028; GRX_PICOT_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR033658; GRX_PICOT-like.
DR InterPro; IPR004480; Monothiol_GRX-rel.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR10293; GLUTAREDOXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10293:SF70; GLUTAREDOXIN-LIKE PROTEIN; 1.
DR Pfam; PF00462; Glutaredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 100..163
FT /note="Glutaredoxin"
FT /evidence="ECO:0000259|Pfam:PF00462"
FT REGION 48..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 195 AA; 21392 MW; 50921AE9007AE3B8 CRC64;
MLPFSYRVLM RGVSAVSGAL SVALQHRALA GTTRSFSSSR PVWLAPAAPT KQAPPAMGGD
TDAEETHPDF QPRMVSSDLA QDEIAMIKKD IDDTIRDEDV VVFIKGVPEA PMCAFSKRMI
DVMEALGVEY TSFDVLAHPV VRSYVKEVSE WPTIPQLFVK GEFAGGVDII LKMAESGDLQ
MLLDQKSIKH RDTKP
//
